2,397 results found
    1. Developmental Biology
    2. Neuroscience

    Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

    Xuecai Ge et al.
    Neuropilin integrates with Hedgehog signal transduction by a newly identified transducer to control cerebellar neurogenesis and medulloblastoma.
    1. Cell Biology

    Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

    Roberto Villaseñor et al.
    Cells package active receptors in endosomes at fairly constant amounts and can determine different cell-fate decisions by regulating the number and lifetime of receptor packages.
    1. Neuroscience

    Spinal microcircuits comprising dI3 interneurons are necessary for motor functional recovery following spinal cord transection

    Tuan V Bui et al.
    A genetically-defined population of spinal interneurons is reciprocally connected with spinal locomotor circuits and mediates recovery of locomotor function following spinal cord transection.
    1. Microbiology and Infectious Disease

    A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane

    Anna Konovalova et al.
    Mutations that block assembly of the interlocked RcsF/β barrel protein complex prevent detection of lipopolysaccharide stress and activation of Rcs signal transduction pathway.
    1. Plant Biology

    Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells

    Benjamin Brandt et al.
    The calcium-dependent signaling pathway during ABA-dependent stomatal closure requires the calcium-independent pathway, and calcium signaling specificity is mediated by PP2C protein phosphatases.
    1. Developmental Biology

    Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification

    Heejin Nam et al.
    Shh, produced by postmitotic spinal neurons, plays crucial roles in the specification of the lateral motor column of the spinal cord through ARHGAP36.
    1. Physics of Living Systems
    2. Microbiology and Infectious Disease

    Phototaxis: Life in focus

    Carol Dieckmann, Telsa Mittelmeier
    Insight
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    1. Cell Biology
    2. Immunology and Inflammation

    Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

    Danielle J Clark et al.
    A membrane-associated, supramolecular protein complex with dynamically changing components, the central supramolecular activation cluster, regulates the generation of the T cell effector cytokine IL-2 depending on its composition.
    1. Cell Biology
    2. Developmental Biology

    Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

    Maia Kinnebrew et al.
    The patched hedgehog receptor inhibits the transmembrane transducer smoothened by reducing the accessibility of cholesterol locally at the membrane of the primary cilium.

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