Neuropilin integrates with Hedgehog signal transduction by a newly identified transducer to control cerebellar neurogenesis and medulloblastoma.

Cells package active receptors in endosomes at fairly constant amounts and can determine different cell-fate decisions by regulating the number and lifetime of receptor packages.

A genetically-defined population of spinal interneurons is reciprocally connected with spinal locomotor circuits and mediates recovery of locomotor function following spinal cord transection.

Mutations that block assembly of the interlocked RcsF/β barrel protein complex prevent detection of lipopolysaccharide stress and activation of Rcs signal transduction pathway.

The calcium-dependent signaling pathway during ABA-dependent stomatal closure requires the calcium-independent pathway, and calcium signaling specificity is mediated by PP2C protein phosphatases.

A family of engineered immune receptors trigger internalization of cancer cells and antigen-coated targets.

Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.

NETs induction, a central component of the innate immune response, utilises assorted signalling pathways as demonstrated through the analysis of healthy and patient neutrophils treated with five distinct stimuli.