3,168 results found
    1. Cell Biology
    2. Physics of Living Systems

    A mechano-osmotic feedback couples cell volume to the rate of cell deformation

    Larisa Venkova, Amit Singh Vishen ... Matthieu Piel
    Whether deforming cells behave as elastic balls (deforming at constant volume) or as sponges (loosing volume as they deform) depends on how fast they change their shape, because the cell volume depends on the tension of the plasma membrane.
    1. Neuroscience

    Disynaptic cerebrocerebellar pathways originating from multiple functionally distinct cortical areas

    Julia U Henschke, Janelle MP Pakan
    Anatomical projections from sensory, motor, and association cortex to the cerebellum are precisely mapped, including cortical-precerebellar connections and terminal organization, providing insight into how the cerebellum may utilize cortical information.
    1. Neuroscience

    A reservoir of timescales emerges in recurrent circuits with heterogeneous neural assemblies

    Merav Stern, Nicolae Istrate, Luca Mazzucato
    The large range of timescales empirically observed in neural circuits can be naturally explained when neural assemblies of heterogeneous size are recurrently coupled, empowering the neural circuits to efficiently process complex time-varying input signals.
    1. Neuroscience

    Mechanisms underlying sharpening of visual response dynamics with familiarity

    Sukbin Lim
    Changes in neural response dynamics observed with visual learning provide a novel means to dissect synaptic plasticity and its interplay with slow negative feedback via firing rate adaptation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Genetic basis and dual adaptive role of floral pigmentation in sunflowers

    Marco Todesco, Natalia Bercovich ... Loren H Rieseberg
    Variation in patterns of floral UV pigmentation is controlled by a single transcription factor in sunflower and affects both pollinator attraction and responses to environmental stresses.
    1. Neuroscience

    Hippocampal place cell remapping occurs with memory storage of aversive experiences

    Garrett J Blair, Changliang Guo ... Hugh T Blair
    Imaging of neurons within the hippocampus, a memory region of the brain, reveals how the brain updates memories during different learning conditions compared to when learning is blocked by amnestic drugs.
    1. Developmental Biology

    Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary

    Yulong Liu, Michelle E Kossack ... Bruce W Draper
    Single-cell transcriptomics of the zebrafish ovary identifies both major and minor cell types and provides a valuable resource for researchers interested in reproductive biology, stem cell biology, and aquatic toxicology.
    1. Neuroscience

    A circuit mechanism for decision-making biases and NMDA receptor hypofunction

    Sean Edward Cavanagh, Norman H Lam ... Steven Wayne Kennerley
    Ketamine, an NMDA receptor antagonist and experimental model for schizophrenia, produces decision-making deficits in monkeys, which are predicted by a lowering of cortical excitation-inhibition balance in a spiking circuit model.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

    Qiaozhen Ye, Scott C Rosenberg ... Kevin D Corbett
    TRIP13 inactivates the spindle assembly checkpoint by converting MAD2 from its active ‘closed’ state to its inactive ‘open’ state.
    1. Developmental Biology
    2. Neuroscience

    Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

    Baruch Haimson, Yoav Hadas ... Avihu Klar
    Spinal dI2 interneurons relay peripheral and intraspinal feedback to premotor networks in the spinal cord and the cerebellum to ensure the stability of bipedal stepping.

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