Browse the search results

Page 2 of 317
    1. Genetics and Genomics

    A method for low-coverage single-gamete sequence analysis demonstrates adherence to Mendel’s first law across a large sample of human sperm

    Sara A Carioscia, Kathryn J Weaver ... Rajiv C McCoy
    A computational method and genome-wide scan of low-coverage single-cell sequencing data from a large sample of human sperm suggests balanced transmission of alleles to the gamete pool.
    1. Cell Biology
    2. Computational and Systems Biology

    Limits on information transduction through amplitude and frequency regulation of transcription factor activity

    Anders S Hansen, Erin K O'Shea
    The ability of cells to transmit information encoded in signaling dynamics is fundamentally limited by the gene decoding step.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system

    Joseph Crispell, Clare H Benton ... Rowland Raymond Kao
    Analyses combining genomic and epidemiological data of Mycobacterium bovis, which causes bovine tuberculosis, revealed evidence of transmission within and between cattle and badger populations.
    1. Neuroscience

    BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk

    Qing-Tao Meng, Xian-Yu Liu ... Zhou-Feng Chen
    B-type natriuretic peptide (BNP) modulates itch via BNP-NPRC pathway by enhancing NMB-NMBR signaling, which is independently of gastrin-releasing peptide (GRP)-GRPR signaling in the spinal cord.
    1. Cell Biology
    2. Computational and Systems Biology

    Signaling Systems: Transferring information without distortion

    Steven S Andrews, Roger Brent, Gábor Balázsi
    Despite employing diverse molecular mechanisms, many different cell signaling systems avoid losing information by transmitting it in a linear manner.
    Version of Record
    Insight
    1. Cell Biology

    Cross-compartment signal propagation in the mitotic exit network

    Xiaoxue Zhou, Wenxue Li ... Angelika Amon
    The mitotic exit network signals from spindle pole bodies to the nucleolus through the dynamic localization of its terminal kinase complex Dbf2-Mob1.
    1. Evolutionary Biology

    Symptom evolution following the emergence of maize streak virus

    Adérito L Monjane, Simon Dellicour ... Darren P Martin
    Phylogenetic analyses demonstrate an evolutionary trade-off between the amount of harm inflicted by a broad host-range virus and how effectively the virus positions itself within plants to enable onward transmission.
    1. Neuroscience

    Single spikes drive sequential propagation and routing of activity in a cortical network

    Juan Luis Riquelme, Mike Hemberger ... Julijana Gjorgjieva
    Single-neuron spikes in a network model of the turtle cortex trigger reliable, yet flexible sequences of activity through a sparse backbone of strong synaptic connections.
    1. Physics of Living Systems
    2. Developmental Biology

    Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

    Tae-Jin Kim, Chirlmin Joo ... Yingxiao Wang
    Deep penetration and transmission of mechanical force to regulate ER functions depends on not only the passive cytoskeletal support, but also the active actomyosin contractility, which is dispensable for mechanotransduction at the plasma membrane.
    1. Neuroscience

    Dopamine neuron dependent behaviors mediated by glutamate cotransmission

    Susana Mingote, Nao Chuhma ... Stephen Rayport
    The conditional reduction of glutaminase in mouse dopamine neurons selectively attenuates glutamate cotransmission at phasic frequencies, revealing the role of dopamine neuron glutamate cotransmission in the attribution of motivational salience.