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    1. Cell Biology
    2. Developmental Biology

    Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to early lethality in mice

    Hyung-seok Kim, Mary Sanchez ... Jan L Christian
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cell Biology

    Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

    Joan Chang, Adam Pickard ... Karl E Kadler
    Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in fibrotic fibroblasts.
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cell Biology

    Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

    Masroor Ahmad Paddar, Fulong Wang ... Vojo Deretic
    Membrane atg8ylation but not canonical autophagy control retromer-dependent endosomal sorting of cargo, including glucose transporter GLUT1, of general import and of significance for control of tuberculosis.
    1. Neuroscience

    Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis

    Jian Dong, Miao Chen ... Matthijs Verhage
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

    Elise S Bruguera, Jacob P Mahoney, William I Weis
    Biophysical binding and structural prediction studies reveal that Tetraspanin12 directly binds the ligand Norrin, in a manner that is negatively cooperative with Norrin-Fzd4 binding and competitive with Norrin-LRP5/6 binding.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

    Leonid Peshkin, Enrico Maria Daldello ... Catherine Jessus
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Axonal injury signaling is restrained by a spared synaptic branch

    Laura J Smithson, Juliana Zang ... Catherine A Collins
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

    John Yong, Jacqueline E Villalta ... Calvin H Jan
    Genome-wide CRISPRi screens and proteome profiling of lysosomes link lipid dysregulation to ESCRT disruption and proteostasis defect.
    1. Immunology and Inflammation

    Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment

    Matteo Napoli, Roland Immler ... Monika Pruenster
    Cytosolic S100A8/A9 enhances Ca2+ availability at LFA-1 adhesion sites, facilitating neutrophil recruitment and extravasation by supporting proper integrin signaling and cytoskeletal rearrangement.
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