The autophagosomal membrane becomes negatively charged during maturation due to the accumulation of PI4P, leading to the recruitment of syntaxin 17, which is required for autophagosome-lysosome fusion.
Identified as a binding factor of transcription factor MYRF, the LRR-TM protein PAN-1 promotes the cell-membrane localization and nuclear translocation of MYRF, which drives synaptic rewiring in Caenorhabditis elegans.
Nanoscaleimaging reveals that animal septins form dense filamentous networks on biomimeticlipid membranes, explaining how septins may regulate cell surface rigidity.
Sytse J Piersma, Jennifer Poursine-Laurent ... Wayne M Yokoyama
Cytomegaloviruses are recognized by distinct sensors depending on the infected cell type and together these sensors are essential for viral control and downstream immune responses.
Local deep hypothermia combined with hibernation-mimicking cold protection is neuroprotective in a translatable large animal model of traumatic optic neuropathy.
The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.
Intracellular growth of the bacterial pathogen Legionella pneumophila in the amoeba Dictyostelium discoideum implicates a bacterial fatty acid transporter as well as dynamic interactions of the distinct membrane-bound replication compartment with host cell lipid droplets.
Anthony J Veltri, Karole N D'Orazio ... Rachel Green
Genetic screens and functional assays utilizing reporter mRNAs triggering NGD or COMD provide a basis for understanding the unique contributions of each pathway to translation-coupled mRNA decay and contextualizes their effects in the larger cellular process of translation surveillance.
Tatsuya Sato, Jason Solomon Shapiro ... Hossein Ardehali
Aging is associated with mitochondrial and cytosolic iron accumulation in the brain, which is through increased local expression of hepcidin, and subsequent iron accumulation due to decreased iron export through ferroportin-1.
