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Information transduction capacity of mammalian cells is high and varies substantially from cell to cell.

Mechanotransduction signaling analysis suggests that mechanical tension can sensitize, desensitize, and reverse cell responses to biochemical agonists, as well as provide mechano-adaptive targets for regionally specific drug responses.

CX3CR1-positive dendritic cells are altered in patients with non-infectious uveitis.

A novel RNA-based trans-regulatory system that control gene expression in mammalian cells has been developed and they can be coupled to endogenous signals.

The powerful computational operation of sequence recognition on behavioral timescales of approximately 1 s may emerge from synaptic activity-triggered build-up of biochemical waves in short 20 micron zones on dendrites.

Tissue-specific temporal regulators impinge on the VEGF/Delta-Notch pathway to vary tip cell selection pace yielding diverse densities of vascular network.

KinCytE is a web-based platform that explores kinase-cytokine-driven signaling and its relevance to understanding and treating diseases linked to disruptions in these pathways.

Data-driven systems biology models of signaling predict cellular response to untested perturbations and can nominate drug combinations to overcome drug resistance in cancer cells.

Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.

Novel brainstem organotypic cultures that generate rhythmic respiratory motor activity reveal the neural networks that control breathing and a new pathway in the hypercapnic response.