1,919 results found
    1. Ecology

    Meta-analysis challenges a textbook example of status signalling and demonstrates publication bias

    Alfredo Sánchez-Tójar et al.
    Meta-analysis takes down a textbook example in behavioural and evolutionary ecology, and demonstrates the existence of biases in the current scientific publishing culture.
    1. Developmental Biology
    2. Immunology and Inflammation

    Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors

    Divyanshu Malhotra et al.
    A new form of chemokine signaling bias that depends on cell state is identified.
    1. Biochemistry and Chemical Biology

    Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

    Rajendra Uprety et al.
    The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.
    1. Physics of Living Systems

    Asymmetric random walks reveal that the chemotaxis network modulates flagellar rotational bias in Helicobacter pylori

    Jyot D Antani et al.
    Asymmetric forward and backward swimming speeds reveal that the rotational bias, and not reversal frequencies, is an appropriate measure of chemotaxis signaling in Helicobacter pylori..
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Self-assembling manifolds in single-cell RNA sequencing data

    Alexander J Tarashansky et al.
    An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Gene regulation gravitates toward either addition or multiplication when combining the effects of two signals

    Eric M Sanford et al.
    When two signals increase transcription of the same gene, their combined effect tends to reflect either the sum of the individual increases or the product of the individual fold-changes.
    1. Neuroscience

    Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

    Nathan Cermak et al.
    Simultaneous quantification of each of the main motor programs in the roundworm C. elegans yields new insights into the neural mechanisms that coordinate animal behavior.
    1. Neuroscience

    Persistent coding of outcome-predictive cue features in the rat nucleus accumbens

    Jimmie M Gmaz et al.
    Neural activity in the rat nucleus accumbens provides a rich task representation that includes not only expected outcomes, but also the specific identity of the cues that predict these outcomes.
    1. Cancer Biology

    Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells

    Arun M Unni et al.
    Cancer cells driven by mutations in KRAS or EGFR are dependent on DUSP6 to prevent ERK-induced cell death, creating a novel vulnerability for targeted therapy.
    1. Cell Biology
    2. Immunology and Inflammation

    Deep-learning-based three-dimensional label-free tracking and analysis of immunological synapses of CAR-T cells

    Moosung Lee et al.
    Rapid, label-free, volumetric, and automated assessment of the immunological synapse dynamics is demonstrated by combining optical diffraction tomography and deep-learning-based segmentation, providing a new option for immunological research.

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