Tool behaviour of long-tailed macaques leaves archaeological signatures that differ between populations despite similar ecological conditions, highlighting the potential for diversity in material culture.
Single cell transcriptome analysis of an embryonic collective migratory cell population provides new insights into the heterogeneity of transcriptional signatures within a neural crest cell migratory stream.
Epigenomic signatures overlapping disease-associated variants from genome-wide association studies help prioritize new variants in sub-threshold loci whose biological relevance is experimentally confirmed.
APPPS1 microglia express disease-associated proteomic signatures of Alzheimer's disease earlier, compared to the APP-KI, and these differences correlate with the levels of fibrillar Aβ and impaired microglial phagocytic function.
The discovery and preclinical validation of a novel gene signature predictive for response to HDM2-targeting drug NVP-CGM097 could significantly improve the clinical response rate to all p53-HDM2 inhibitors.