1,277 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    A quantitative modelling approach to zebrafish pigment pattern formation

    Jennifer P Owen et al.
    A mathematical modelling approach to understanding zebrafish stripe pattern formation exemplifies a biological rule-set sufficient to generate wild-type and a diverse range of mutant patterns.
    1. Developmental Biology

    Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

    Marketa Kaucka et al.
    The clonal oriented cell dynamics enables directional expansion and accurate scaling of sheet-like or rod-like cartilaginous elements and uncouples the mechanisms of elongation from thickness or diameter control.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Modulating FOXO3 transcriptional activity by small, DBD-binding molecules

    Judith Hagenbuchner et al.
    The mode of binding and cellular effect of the first FOXO3-DNA-binding-domain targeting small compound discovered by a combined pharmacophore-based/biochemical screening approach is reported.
    1. Neuroscience

    A primal role for the vestibular sense in the development of coordinated locomotion

    David E Ehrlich, David Schoppik
    Zebrafish use their sense of gravity and their cerebellum to coordinate the fin and body movements that, as they develop, allow them to better maintain balance as they climb.
    1. Computational and Systems Biology

    Essential metabolism for a minimal cell

    Marian Breuer et al.
    A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The origins and relatedness structure of mixed infections vary with local prevalence of P. falciparum malaria

    Sha Joe Zhu et al.
    Variation in the rate of mixed infections by malaria parasites and the relatedness structure among infecting strains reveals diversity in local epidemiological processes.
    1. Neuroscience

    A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo

    Pierre Yger et al.
    A spike sorting toolbox to quickly and reliably access the activity of thousands of neurons recorded with dense extracellular probes.
    1. Neuroscience

    Dynamic control of hippocampal spatial coding resolution by local visual cues

    Romain Bourboulou et al.
    Hippocampal spatial coding resolution can quickly adapt to local visual cues within a given environment.
    1. Ecology
    2. Genetics and Genomics

    Viral dark matter and virus–host interactions resolved from publicly available microbial genomes

    Simon Roux et al.
    From public microbial genomes, VirSorter revealed 12,498 viral genome sequences that expand the map of the global virosphere and whose analyses improve understanding of viral taxonomy, evolution and virus-host interactions.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system

    Rupamanjari Majumder et al.
    Free optical steering of spiral waves by attraction-based dragging of their cores in optogenetically modified cardiac tissue.

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