Histones bound to lipid droplets inside cells offer protection against bacteria in flies, and possibly mice, thus suggesting a possible new innate immunity pathway.
A combination of molecular dynamics simulations and X-ray diffraction data has been used to construct more realistic models of proteins and to provide new insights into their interactions with other proteins and biomolecules.
Yael Artzy-Randrup, Mary M Rorick ... Mercedes Pascual
Mathematical modeling shows that local populations of the malaria parasite self-organize into a limited number of transient but distinct strains through competition for hosts in immunity space.
A combination of single-molecule imaging and an in vitro model of the cell cortex has allowed the interactions between actin filaments and filaments made of myosin II to be studied in detail.
Simulations and experiments on systems containing two different populations of microorganisms show that interactions that benefit at least one of the populations can lead to communities with stable compositions, and that strong cooperation between two populations can lead to communities in which both populations are mixed together.
Verena Pawlak, David S Greenberg ... Jason ND Kerr
Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.
Neurons in the hippocampus modulate the rates at which they fire, and the locations in which they fire, so as to encode the information that is central to forming memories about personal experiences.
Tijana Ivanovic, Jason L Choi ... Stephen C Harrison
Long-lived intermediate states formed by glycoprotein catalysts are an essential part of the process used by influenza virus particles to infect cells.
The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain