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    1. Computational and Systems Biology
    2. Medicine

    Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

    Xin Zhou, Zhinuo Jenny Wang ... Blanca Rodriguez
    Human-based electromechanical simulations reveal electrocardiogram biomarkers are better indicators of pro-arrhythmic substrate after myocardial infarction than ejection fraction.
    1. Cell Biology
    2. Computational and Systems Biology

    Artistoo, a library to build, share, and explore simulations of cells and tissues in the web browser

    Inge MN Wortel, Johannes Textor
    By letting users build interactive simulations directly in a web browser, Artistoo unlocks new ways to communicate, teach, and collaborate in computational biology research.
    1. Neuroscience

    Human hippocampal responses to network intracranial stimulation vary with theta phase

    Sarah M Lurie, James E Kragel ... Joel L Voss
    Human hippocampal connectivity to network afferents varies continuously with the phase of the local theta oscillation, confirming a putative mechanism by which neural oscillations modulate human hippocampal function.
    1. Neuroscience

    Brian 2, an intuitive and efficient neural simulator

    Marcel Stimberg, Romain Brette, Dan FM Goodman
    Brian 2 is a software package for neural simulations that makes it both easy and computationally efficient to define original models for computational experiment.
    1. Structural Biology and Molecular Biophysics

    Sublytic gasdermin-D pores captured in atomistic molecular simulations

    Stefan L Schaefer, Gerhard Hummer
    Molecular dynamics simulations reveal the formation of membrane pores by gasdermin-D, the ultimate effector of pyroptotic cell death in inflammation and infection.
    1. Neuroscience

    Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans

    Benjamin R Kop, Yazan Shamli Oghli ... Lennart Verhagen
    Realizing the clinical and neuroscientific potential of transcranial ultrasonic stimulation (TUS) requires careful control of the peripheral auditory confounds that underlie previously reported online motor inhibitory effects.
    1. Neuroscience

    Neural effects of continuous theta-burst stimulation in macaque parietal neurons

    Maria C Romero, Lara Merken ... Marco Davare
    Electrophysiological recordings in awake behaving monkeys show the first evidence of the effect of continuous theta-burst stimulation, a widely used repetitive transcranial magnetic stimulation protocol, at the level of single neurons.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase

    Wen Ma, Kevin D Whitley ... Klaus Schulten
    Integration of structural bioinformatics and free-energy simulations reveals how a helicase switches its function from unwinding to rezipping DNA, during which a key metastable conformation is predicted and verified by single-molecule measurements.
    1. Neuroscience

    Making memories last using the peripheral effect of direct current stimulation

    Alison M Luckey, Lauren S McLeod ... Sven Vanneste
    Non-invasive transcutaneous electrical stimulation of the greater occipital nerve using direct current promotes strengthening of memories using late-phase synaptic activity.
    1. Neuroscience

    Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice

    Jonathan S Schor, Isabelle Gonzalez Montalvo ... Alexandra B Nelson
    In a mouse model of Parkinson's disease, deep brain stimulation of the subthalamic nucleus disrupts movement-related neural activity in parallel with relieving motor symptoms.