1,890 results found
    1. Microbiology and Infectious Disease

    Mechanistic Microbiome Studies: A Special Issue

    Edited by Wendy S Garrett et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of microbiome function.
  1. Episode 48: June 2018

    In this episode, we hear about why we always have space for dessert, how collecting seeds from large areas could help restoration projects, gut bacteria, the placebo effect and toxoplasmosis.
  2. June 2013

    Episode 1: June 2013

    In the first eLife podcast we hear about the origins of multicellularity, the Irish potato famine, hepatitis viruses, how fog affects the behaviour of car drivers, and the evolution of chromatin.
  3. January 2015

    Episode 17: January 2015

    In this episode we hear about controlling sperm by optogenetics, hibernation, body clocks, enzyme structure, and a way to overcome stress-induced infertility.
    1. Cell Biology

    Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation

    Maria Fomicheva, Ian G Macara
    TRAF3, a negative regulator of noncanonical NF-κB signaling, maintains epithelial cell quiescence at confluence, and its loss triggers upregulation of immunity genes and prevents entry into G0 at high cell density.
    1. Computational and Systems Biology
    2. Developmental Biology

    Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

    Sumeda Nandadasa et al.
    Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
    1. Biochemistry and Chemical Biology

    Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria

    Kyle Mangano et al.
    Inhibition of bacterial protein synthesis by an antimicrobial peptide apidaecin triggers translation arrest at the stop codons, ribosome queuing and pervasive stop codon readthrough.
    1. Cancer Biology

    Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma

    Connor Rogerson et al.
    Genome-wide redistribution of KLF5 binding leads to activation of a cell cycle gene expression programme and proliferation control in oesophageal cancer.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic mapping of etiologic brain cell types for obesity

    Pascal N Timshel et al.
    Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

    Osama F Harraz et al.
    TRPV4 channels in brain capillaries are suppressed by the phosphoinositide PIP2 and activated by receptor agonists implicated in neurovascular coupling.

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