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Computational and Systems Biology
Stem Cells and Regenerative Medicine
Self-assembling manifolds in single-cell RNA sequencing data
Alexander J Tarashansky et al.
An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
The Natural History of Model Organisms: The unlimited potential of the great pond snail,
István Fodor et al.
The great pond snail is a multipurpose model organism and a contemporary choice for addressing a wide range of biological questions, problems and phenomena in the laboratory and the field.
Endosymbiosis: Gasping for air
Steven G Ball, Ugo Cenci
Transcriptomics is shedding new light on the relationship between photosynthetic algae and salamander eggs.
Transcriptomics: Resting easy with a sleep regulator
William J Giardino, Luis de Lecea
Chromosomes and Gene Expression
Regulatory Evolution: Yeast rises to the occasion
Mark A Ragan
The Natural History of Model Organisms: The house sparrow in the service of basic and applied biology
Haley E Hanson et al.
The house sparrow, one of the most ubiquitous birds in the world, is now used extensively in studies across disciplines in the life sciences.
The Natural History of Model Organisms: Insights into the evolution of social systems and species from baboon studies
Julia Fischer et al.
Wild baboons are an excellent model to study complex evolutionary processes such as speciation and hybridization, as well as the links between sociality, longevity and reproductive success.
The Natural History of Model Organisms:
, an 'instant' fish from an ephemeral habitat
Martin Reichard, Matej Polačik
The turquoise killifish from ephemeral pools in African savannah combines extremely short lifespan with a standard vertebrate body plan – ideal attributes for a laboratory animal.
Genetics and Genomics
The Natural History of Model Organisms: The untapped potential of medaka and its wild relatives
Leon Hilgers, Julia Schwarzer
Studies of medaka and other ricefishes in the wild could provide insights in fields such as evolutionary biology, development and cancer research.
Biochemistry and Chemical Biology
Origin of life: Transitioning to DNA genomes in an RNA world
Razvan Cojocaru, Peter J Unrau
The unexpected ability of an RNA polymerase ribozyme to copy RNA into DNA has ramifications for understanding how DNA genomes evolved.
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