2,462 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

    Hannah K Long, David Sims ... Robert J Klose
    Islands of non-methylated DNA are shown to perform a similar epigenetic role in many different vertebrate species.
    1. Neuroscience

    Convergence of pontine and proprioceptive streams onto multimodal cerebellar granule cells

    Cheng-Chiu Huang, Ken Sugino ... Adam W Hantman
    Individual granule cells within the cerebellum-the region of the brain that coordinates movement and supports the learning of new motor skills-receive both sensory and motor input streams: an arrangement that may help the brain to use feedback to fine-tune movement.
    1. Chromosomes and Gene Expression

    A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

    Nicole A Rapicavoli, Kun Qu ... Howard Y Chang
    A long non-coding RNA regulates the expression of genes that encode proteins involved in the inflammatory response.
    1. Stem Cells and Regenerative Medicine
    2. Microbiology and Infectious Disease

    Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni

    Bo Wang, James J Collins III, Phillip A Newmark
    Cells that give rise to the infectious form of parasitic flatworms called schistosomes show similar patterns of gene expression to stem cells in free-living flatworms.
    1. Developmental Biology

    Cellular resolution models for even skipped regulation in the entire Drosophila embryo

    Garth R Ilsley, Jasmin Fisher ... Nicholas M Luscombe
    A statistical model is able to predict patterns of gene expression output in Drosophila embryos using only the cellular concentrations of transcription factors as input.
    1. Stem Cells and Regenerative Medicine

    Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species

    Ricardo Antonio Rosselló, Chun-Chun Chen ... Erich D Jarvis
    Cells from vertebrate and invertebrate model systems can be reprogrammed into stem-like cells using mouse genes.
    1. Genetics and Genomics
    2. Plant Biology

    Cytoplasmic genetic variation and extensive cytonuclear interactions influence natural variation in the metabolome

    Bindu Joseph, Jason A Corwin ... Daniel J Kliebenstein
    Genes located within cellular organelles impact phenotype more than expected due to their interactions with nuclear genes.
    1. Microbiology and Infectious Disease

    Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse

    Jingtao Lilue, Urs Benedikt Müller ... Jonathan C Howard
    Mechanisms that enable wild mice to survive infection with strains of the Toxoplasma gondii parasite virulent enough to kill laboratory mice offer an explanation for how these parasites have been able to persist in the mouse population.
    1. Biochemistry and Chemical Biology

    Global cellular response to chemotherapy-induced apoptosis

    Arun P Wiita, Etay Ziv ... James A Wells
    The simultaneous monitoring of transcription, translational control, protein production and proteolysis in the same system can improve our understanding of how cancer cells respond to chemotherapy.
    1. Developmental Biology

    Developmental lineage priming in Dictyostelium by heterogeneous Ras activation

    Alex Chattwood, Koki Nagayama ... Christopher RL Thompson
    The probability of a cellular response to a differentiation inducing signal is correlated with the dynamic expression of a Ras protein, and produces a ‘salt and pepper’ pattern of cell differentiation.

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