A single-cell transcriptome atlas reveals meniscal microenvironment variations during degeneration and cellular heterogeneity foundations of the inner–outer zone differences, suggesting novel cell subtypes as potential therapeutic targets.
A previously unrecognized subpopulation of fibroblasts that immediately responded to stimuli from mouse periodontitis models and activated the Toll-like receptor signaling and chemokine expression to guide oral barrier immunity and gingival inflammation was revealed by mouse gingival single-cell transcriptomic atlas.
Single-cell RNA-sequencing unraveled cell subtype-specific transcriptomic changes in both injured and uninjured primary sensory neurons after nerve injury and demonstrated transcriptomic sexual dimorphism.
Dermal preadipocytes produce T cell chemokines in response to IFNγ, driving the recruitment and activation of type 1 effector T cells in allergic contact dermatitis.
Stephen J Smith, Uygar Sümbül ... Michael Hawrylycz
Single-cell mRNA sequencing data from mouse neocortex expose evidence for peptidergic neuromodulation networks that locally interconnect every cortical neuron.
The molecular, cellular, and spatial heterogeneity of adult human spinal cord serve as an important resource to explore the mechanisms underlying spinal cord physiology and diseases.
Chananchida Sang-aram, Robin Browaeys ... Yvan Saeys
Estimating cell type composition from a gene expression mixture remains a challenging task, as evidenced by how a simple regression model outperforms many state-of-the-art spatial deconvolution methods.
