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    1. Developmental Biology
    2. Neuroscience

    Tuning of delta-protocadherin adhesion through combinatorial diversity

    Adam J Bisogni et al.
    Combinatorial expression patterns of δ-Pcdhs are defined within single neurons, and in vitro assays are employed to establish guiding principles used by this gene family to mediate cell adhesion.
    1. Neuroscience

    Neuronal activity determines distinct gliotransmitter release from a single astrocyte

    Ana Covelo, Alfonso Araque
    A single astrocyte can decode neuronal activity and, consequently, release distinct gliotransmitters that differentially regulate neurotransmission at single hippocampal synapses.
    1. Neuroscience

    Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

    Verena Pawlak et al.
    Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.
    1. Neuroscience

    Resolving rates of mutation in the brain using single-neuron genomics

    Gilad D Evrony et al.
    The reanalysis of data from a recent study that claimed retrotransposon mutations are ubiquitous in the human brain outlines a general framework for the design and analysis of single-cell genomics studies.
    1. Neuroscience

    Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus

    Laura E Mickelsen et al.
    Single cell RNA–sequencing and neuroanatomical methods reveal unexpected molecular diversity and highly segregated spatial organization of neuronal cell types within the mouse ventral posterior hypothalamus, including the mammillary nuclei.
    1. Neuroscience

    Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice

    Sean E Cavanagh et al.
    Variability in individual neurons' temporal receptive fields of integration is found to explain the heterogeneity of neuronal responses observed in prefrontal cortex during reward-guided decision making.
    1. Neuroscience

    Neural encoding of actual and imagined touch within human posterior parietal cortex

    Srinivas Chivukula et al.
    Single neurons in human posterior parietal cortex encode actual and imagined touch within a shared neural substrate.
    1. Neuroscience

    Phase-tuned neuronal firing encodes human contextual representations for navigational goals

    Andrew J Watrous et al.
    Prospective navigational goals are represented by single neuron firing rates and firing relative to slow oscillatory phase (phase coding) in the human medial temporal lobe.
    1. Stem Cells and Regenerative Medicine

    Mouse embryonic stem cells can differentiate via multiple paths to the same state

    James Alexander Briggs et al.
    Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
    1. Neuroscience

    Distinct neural networks for the volitional control of vocal and manual actions in the monkey homologue of Broca's area

    Natalja Gavrilov, Andreas Nieder
    Single-neuron recordings in the inferior frontal cortex of trained macaques show neurons that are selective to the volitional preparation of either vocal or manual actions.