New open-source method contains all the tools for extracting open chromatin or RNA from thousands of single cells in parallel for <5% of the cost of state-of-the-art commercial alternatives, paving the way for whole-tissue atlasing and new protocol development.
Adult neural stem cells differ in the types of neurons they generate according to their location and new territories and genes associated with dorsal and ventral neurogenic lineages in the adult mouse brain are revealed.
The COVID Tissue Atlas Consortium, Alejandro A Granados ... Bruce Wang
A conserved transcriptional signature in macrophages and endothelial cells occurs in multiple organs in response to COVID-19 and suggests potential molecular interactions between the two cell types.
Gene expression and epigenetic profiling of defined cell types in the central nervous system of mouse, rat, and human reveals inter-species and inter-individual differences.
A cellular map of a deep-sea mussel gill unveils how distinct cell types collaborate to cultivate intracellular symbiotic bacteria, providing insights into host–symbiont interactions and environmental adaptation in bivalves.
Reanalysis reveals the impact of quality control and differential analysis methods on the discovery of disease-associated genes on the first Alzheimer's disease single-nucleus RNA-seq dataset.
Molecular and spatial profiling methods idenified five neuronal subtypes that are distributed along the anteroposterior axis of the paraventricular thalamus, a structure increasingly implicated in the control of emotional and motivated behaviors.
A brown-to-white adipogenic transdifferentiation process in the periureter region of mouse renal adipose tissue gives rise to a population of cold-inducible adipocytes with a transcriptome distinct from subcutaneous beige adipocytes.
Nuclear pore complex mimics based on solid-state nanopores show significant selectivity below a diameter of 55 nm, which decreases gradually for larger pore diameters.
