Deciphering the mechanism of action of a large family of natural and synthetic cytotoxic lipids bioactivated by enantiospecific oxidation into protein-reactive species inspires the development of enzyme-specific prodrugs.
A powerful sequencing approach is used to elucidate the genetic basis of a complex organismal trait, and members of the irld gene family that affect starvation resistance are identified.
Outer membrane vesicles serve as decoys to reduce the chance of direct polymyxin B (PMB) binding to cells, which partly explains why many clinical isolates and microbial communities can be protected against PMB treatment.
J Dylan Shropshire, Brittany Leigh, Seth R Bordenstein
This review serves as a gateway to experimental, conceptual, and quantitative themes of cytoplasmic incompatibility (CI) and outlines significant gaps in the understanding of CI's mechanism that are ripe for investigation.
In bacteria, frequent adaptive copy-number mutations can hinder the fixation of beneficial point mutations and hence the divergence of duplicated DNA sequences.
Fast and flexible estimation of effective migration surfaces (FEEMS) is a new statistical method that can quickly infer and visualize patterns of migration from genetic data with spatial coordinates.
Cori K Cahoon, Colette M Richter ... Diana E Libuda
Developing eggs and sperm differentially regulate specific steps of meiotic DNA repair by altering the composition and dynamics of proteins within synaptonemal complex.