851 results found
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Biochemistry and Chemical Biology

    SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

    Pascal Demange, Etienne Joly ... Sébastien Britton
    Deciphering the mechanism of action of a large family of natural and synthetic cytotoxic lipids bioactivated by enantiospecific oxidation into protein-reactive species inspires the development of enzyme-specific prodrugs.
    1. Developmental Biology
    2. Genetics and Genomics

    Using population selection and sequencing to characterize natural variation of starvation resistance in Caenorhabditis elegans

    Amy K Webster, Rojin Chitrakar ... L Ryan Baugh
    A powerful sequencing approach is used to elucidate the genetic basis of a complex organismal trait, and members of the irld gene family that affect starvation resistance are identified.
    1. Epidemiology and Global Health

    From multiplicity of infection to force of infection for sparsely sampled Plasmodium falciparum populations at high transmission

    Qi Zhan, Kathryn E Tiedje ... Mercedes Pascual
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii

    Jaeeun Park, Misung Kim ... Woojun Park
    Outer membrane vesicles serve as decoys to reduce the chance of direct polymyxin B (PMB) binding to cells, which partly explains why many clinical isolates and microbial communities can be protected against PMB treatment.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Symbiont-mediated cytoplasmic incompatibility: What have we learned in 50 years?

    J Dylan Shropshire, Brittany Leigh, Seth R Bordenstein
    This review serves as a gateway to experimental, conceptual, and quantitative themes of cytoplasmic incompatibility (CI) and outlines significant gaps in the understanding of CI's mechanism that are ripe for investigation.
    1. Epidemiology and Global Health

    Measuring changes in Plasmodium falciparum census population size in response to sequential malaria control interventions

    Kathryn E Tiedje, Qi Zhan ... Karen P Day
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Evolutionary Biology

    Adaptation dynamics between copy-number and point mutations

    Isabella Tomanek, Călin C Guet
    In bacteria, frequent adaptive copy-number mutations can hinder the fixation of beneficial point mutations and hence the divergence of duplicated DNA sequences.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Fast and flexible estimation of effective migration surfaces

    Joseph Marcus, Wooseok Ha ... John Novembre
    Fast and flexible estimation of effective migration surfaces (FEEMS) is a new statistical method that can quickly infer and visualize patterns of migration from genetic data with spatial coordinates.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Sexual dimorphic regulation of recombination by the synaptonemal complex in C. elegans

    Cori K Cahoon, Colette M Richter ... Diana E Libuda
    Developing eggs and sperm differentially regulate specific steps of meiotic DNA repair by altering the composition and dynamics of proteins within synaptonemal complex.

Refine your results by:

Type
Research categories