Browse the search results

Methylated CpG sites are saturated for T mutations in a sample of 390K human exomes, providing a test case for inferences about fitness effects in human genes, and insight into the interpretation of mutations as pathogenic using reference datasets.

An innovative strategy in genome analysis has generated a detailed description of how pathogens mutate when facing human genetic diversity.

Disentangling the different selective forces shaping the evolutionary dynamics of transposable elements (TEs) in the wild grass Brachypodium distachyon.

Heterozygosity changes the balance between interfering and non-interfering crossovers during Arabidopsis meiosis.

Environmentally responsive genes evolve under strong selective constraint in Arabidopsis lyrata.

Selfish genetic elements may either promote or prevent the evolution of reproductive barriers, depending on the extent of gene flow between species.

Natural selection shaped CHC22 clathrin genetic variation in humans with different diets and potentially influenced the human insulin response.

The first example of an animal where RNA-editing dramatically reshapes the entire proteome demonstrates that editing must be a critical evolutionary and adaptive force.

Analysis of 458 Kalinago provides new insights into the population's genetic structure, the contribution of Native American ancestry to skin pigmentation, and the identification of a coding variant in OCA2 with an estimated –8 melanin units effect size.

Biochemical and in planta studies reveal how a rice immune receptor pair has coevolved to deliver immune responses, an important step towards understanding and engineering bespoke resistance to crop pathogens that threaten food security.