780 results found
    1. Structural Biology and Molecular Biophysics

    Routine single particle CryoEM sample and grid characterization by tomography

    Alex J Noble et al.
    Fiducial-less tomography on single particle cryoEM samples reveals that most particles are adsorbed to the air-water interface and allows for researchers to diagnose and solve sample, grid, ice thickness, collection, and processing issues.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    TRiC’s tricks inhibit huntingtin aggregation

    Sarah H Shahmoradian et al.
    Cryo-electron tomography reveals how a chaperone protein called TRiC reduces the ability of pathogenic mutant huntingtin proteins to form aggregates.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Ancient DNA reveals the lost domestication history of South American camelids in Northern Chile and across the Andes

    Paloma Diaz-Maroto et al.
    aDNA revealed a model of domestication where an ancient guanaco population no longer exists, the loss of the ancient vicuña genetic variation in the modern populations, and frequently interbreeding practices.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate

    Mark S Ladinsky et al.
    Visualization of HIV-1 fusion by trapping the prehairpin intermediate.
    1. Structural Biology and Molecular Biophysics

    Structure of a type IV pilus machinery in the open and closed state

    Vicki AM Gold et al.
    Electron cryo-tomography reveals a huge conformational change in the secretin domain of the type IV pilus machinery that occurs when the channel opens for pilus extrusion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation

    Yashar Sadian et al.
    Imaging with electron microscopy and cryo-electron tomography reveals that competition between Cdc42 and Gic1 for the same subunit within septins controls the formation and breakdown of septin filaments.
    1. Cell Biology
    2. Developmental Biology

    Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy

    Claudia Prahst et al.
    Improved 3D and 4D imaging of neurovascular processes across scales reveals new insights into eye disease mouse models and shows retinal vessels are significantly distorted using standard flat-mount confocal imaging.
    1. Neuroscience

    Temporal cascade of frontal, motor and muscle processes underlying human action-stopping

    Sumitash Jana et al.
    The sequence of neural and physiological processes underlying action-stopping has been delineated.
    1. Evolutionary Biology

    Computed tomography shows high fracture prevalence among physically active forager-horticulturalists with high fertility

    Jonathan Stieglitz et al.
    High reproductive effort constrains bone tissue response to physical activity-induced mechanical loading.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

    Nicholas R Ader et al.
    Correlative microscopy and electron cryo-tomography on apoptotic HeLa cells reveal remodeling of outer and inner mitochondrial membranes, Bax cluster ultrastructure and ATP synthase reorganization in ruptured mitochondria.

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