Characterization of Tnc as a selective integrin ligand at the Drosophila NMJ allows for unprecedented insights into our understanding of extracellular matrix/integrin interactions at synaptic locations and reveals novel, distinct presynaptic and postsynaptic integrin functions.
Benjamin Bessières, Emmanuel Cruz, Cristina M Alberini
Hippocampal metabolomic analyses following episodic learning at different ages revealed a critical role for neuronal glutathione reductase activity in long-term infantile memory formation.
David Willemsen, Rongfeng Cui ... Dario Riccardo Valenzano
Population genetics in turquoise killifish wild populations reveals how small population size and genetic drift determine the accumulation of deleterious gene variants leading to short lifespan.
Irene Cumplido-Mayoral, Marina García-Prat ... OASIS study
Brain-Age delta is a non-invasive marker of biological brain aging that is sensitive to the presence of risk factors and altered biomarkers of Alzheimer's disease in non-demented individuals.
A novel auto-inhibitory mechanism regulates the functional activity of the cellular prion protein, PrPC, providing for the first time a coherent molecular model for both its pathological and physiological effects.
Gradient decomposition of informational connectivity reveals that the principal gradient with the separation of default mode network from sensory-motor systems represents a hallmark of the retrieval of strong conceptual links.