4,157 results found
    1. Cell Biology

    Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly

    Sari Tojkander, Gergana Gateva ... Pekka Lappalainen
    Mechanosensitive inhibition of actin polymerization through VASP phosphorylation is required for stress fiber maturation and alignment.
    1. Cell Biology
    2. Neuroscience

    Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction

    Qi Wang, Tae Hee Han ... Mihaela Serpe
    Characterization of Tnc as a selective integrin ligand at the Drosophila NMJ allows for unprecedented insights into our understanding of extracellular matrix/integrin interactions at synaptic locations and reveals novel, distinct presynaptic and postsynaptic integrin functions.
    1. Neuroscience

    Metabolomic profiling reveals a differential role for hippocampal glutathione reductase in infantile memory formation

    Benjamin Bessières, Emmanuel Cruz, Cristina M Alberini
    Hippocampal metabolomic analyses following episodic learning at different ages revealed a critical role for neuronal glutathione reductase activity in long-term infantile memory formation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Intra-species differences in population size shape life history and genome evolution

    David Willemsen, Rongfeng Cui ... Dario Riccardo Valenzano
    Population genetics in turquoise killifish wild populations reveals how small population size and genetic drift determine the accumulation of deleterious gene variants leading to short lifespan.
    1. Medicine
    2. Neuroscience

    Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer’s disease and neurodegeneration stratified by sex

    Irene Cumplido-Mayoral, Marina García-Prat ... OASIS study
    Brain-Age delta is a non-invasive marker of biological brain aging that is sensitive to the presence of risk factors and altered biomarkers of Alzheimer's disease in non-demented individuals.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells

    Jihoon Shin, Tae Wan Kim ... Hong-Duk Youn
    The regulation of the core transcription factor Oct4 by the Aurkb-PP1 axis links the cell cycle to pluripotency programs in embryonic stem cells.
    1. Cell Biology
    2. Developmental Biology

    A novel mechanism of bulk cytoplasmic transport by cortical dynein in Drosophila ovary

    Wen Lu, Margot Lakonishok ... Vladimir I Gelfand
    Cortical dynein performs bulk cytoplasmic transport by gliding microtubules along the cell cortex and through the ring canals to the oocyte.
    1. Neuroscience

    The N-terminus of the prion protein is a toxic effector regulated by the C-terminus

    Bei Wu, Alex J McDonald ... David A Harris
    A novel auto-inhibitory mechanism regulates the functional activity of the cellular prion protein, PrPC, providing for the first time a coherent molecular model for both its pathological and physiological effects.
    1. Neuroscience

    A parabrachial to hypothalamic pathway mediates defensive behavior

    Fan Wang, Yuge Chen ... Zhihua Gao
    Neural circuit research reveals a previously unrecognized role for the LPBCCK-PVN pathway in controlling defensive behaviors.
    1. Neuroscience

    Flexing the principal gradient of the cerebral cortex to suit changing semantic task demands

    Zhiyao Gao, Li Zheng ... Elizabeth Jefferies
    Gradient decomposition of informational connectivity reveals that the principal gradient with the separation of default mode network from sensory-motor systems represents a hallmark of the retrieval of strong conceptual links.

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