1,859 results found
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation

    Shengbo He et al.
    Transposon activation during male gametogenesis is caused by interactions between DNA demethylation and linker histone H1, developmental depletion of which promotes pollen fertility.
    1. Biochemistry and Chemical Biology

    The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation

    Mikael Holm et al.
    The antibiotic viomycin induces errors during initial codon selection by the ribosome by locking the monitoring bases in their active conformation.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

    Disi An et al.
    Stem cell-derived motor neurons with differential ALS vulnerability identified proteasome activity as a possible mechanism that explains their differential sensitivity.
    1. Cell Biology
    2. Neuroscience

    Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function

    Mroj Alassaf et al.
    Hair cell survival and mitochondrial function is supported by an extracellular stimulator of IGF1 signaling, the protease pregnancy-associated plasma protein-aa.
    1. Microbiology and Infectious Disease

    CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

    David O Ajasin et al.
    Effect of CCL2 on HIV-1 replication is mediated by mobilization of ALIX from F-actin leading to enhanced virion release and improved fitness and this requires the Gag late motif, LYPX.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay

    Jirka Peschek, Peter Walter
    Interconnected RNA processing mechanisms ensure the fidelity of non-conventional mRNA splicing during the unfolded protein response.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome plasticity in Candida albicans is driven by long repeat sequences

    Robert T Todd et al.
    Previously uncharacterized long repeat sequences are associated with significant genome variation that can increase fitness and promote antifungal drug resistance in diverse isolates of Candida albicans.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

    Sandra Elizabeth Torres et al.
    Ceapins specifically inhibit the unfolded protein sensor ATF6α by directly tethering the cytosolic domain of ATF6α to ABCD3 in cells and in vitro.
    1. Chromosomes and Gene Expression

    Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1

    Madhusudhan Srinivasan et al.
    In G1 cells, Scc2 loads and maintains cohesin on chromosomes by counteracting a Wapl-independent releasing activity, which is neutralized in S phase by CDK1.

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