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The structure of a large enzyme complex involved in methanogenesis was determined at high resolution by electron cryo-microscopy.

Quantitative analysis of protein and mRNA expression across a minimally perturbed cell cycle in human myeloid cells has identified myeloid-specific and cell cycle-regulated gene expression, including examples of isoform- and phosphorylation-specific regulation, with all data made available in a searchable, online database.

The ERK8 kinase blocks the export of glycosyl-tranferases from the Golgi to the endoplasmic reticulum, and thus subsequent O-glycosylation of proteins that otherwise enhance cell motility and tissue invasion.

The Dengue virus contains discretely folded RNA structures that confer the ability to resist a powerful host cell enzyme and produce a disease-inducing noncoding RNA.

MicroRNAs tightly control the cellular level of homologous recombination (HR) factors in the G1 phase, and failure of this control system results in an ectopic increase in HR proteins in G1 cells leading to impaired DNA repair.

In the liver, microRNAs exert widespread functions in the modulation of phases and amplitudes of clock-controlled gene expression, but their influence on the core clock is remarkably mild.

Retrograde tracing of the neural circuits that control movement of the jaw and tongue reveals how shared premotor neurons help to ensure coordinated muscle activity.

The involvement of SETD2 in an important DNA repair pathway could explain the high frequency of SETD2 mutations in several cancers and may provide an alternative mechanism to evade the p53-mediated checkpoint.

Genome-wide analysis reveals novel functions for a post-translational modification to the carboxy-terminal domain (CTD) of RNA Polymerase II in mammals.

Zebrin-positive cerebellar Purkinje cells fire at lower frequencies than zebrin-negative cells, indicating that cerebellar circuits are not physiologically homogeneous.