11,535 results found
    1. Developmental Biology

    A single-cell atlas of the cycling murine ovary

    Mary E Morris, Marie-Charlotte Meinsohn ... David Pépin
    A survey of the transcriptomic landscape of the mouse ovary at the single-cell level reveals both the cellular complexity of this organs and the dynamic nature of the cellular states that accompany estrous cycling.
    1. Immunology and Inflammation

    Pioneer neutrophils release chromatin within in vivo swarms

    Hannah M Isles, Catherine A Loynes ... Philip M Elks
    Neutrophil swarms form around a single endogenous pioneer neutrophil in vivo, mediated by DNA release from pioneer neutrophils.
    1. Immunology and Inflammation

    Single-cell RNA sequencing analysis of shrimp immune cells identifies macrophage-like phagocytes

    Peng Yang, Yaohui Chen ... Fan Wang
    A novel innate immune cell subset in shrimp shows similarities with human macrophage.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

    Vanessa Dumeaux, Samira Massahi ... Michael T Hallett
    Candida albicans cells respond in two distinct ways to fluconazole exposure where cells enter the Ribo-dominant state characterized by an upregulation of ribosomal-related proteins and processes, or cells enter the Stress-dominant state characterized by the upregulation of stress responses.
    1. Developmental Biology
    2. Neuroscience

    Characterization of cephalic and non-cephalic sensory cell types provides insight into joint photo- and mechanoreceptor evolution

    Roger Revilla-i-Domingo, Vinoth Babu Veedin Rajan ... Kristin Tessmar-Raible
    Molecular, cellular and behavioral genetic approaches in Platynereis dumerilii indicate that r-Opsins can act as ancient, light-dependent modulators of mechanosensation, and suggest that light-independent mechanosensory roles of r-Opsins evolved secondarily.
    1. Developmental Biology
    2. Neuroscience

    Temporal transcriptomic dynamics in developing macaque neocortex

    Longjiang Xu, Zan Yuan ... Xiaozhong Peng
    A useful single-cell resource provides the prenatal macaque different cell types’ gene expression profiles in the parietal cerebral cortex lobe.
    1. Immunology and Inflammation

    Development of a new genotype–phenotype linked antibody screening system

    Takashi Watanabe, Hikaru Hata ... Hidehiro Fukuyama
    A Golden Gate-based dual-expression vector enables rapid screening, which facilitates efficient isolation of high-affinity cross-reactive antibodies for therapeutic or diagnostic use and provides a crucial advance for pandemic preparedness.
    1. Neuroscience

    Patch-walking, a coordinated multi-pipette patch clamp for efficiently finding synaptic connections

    Mighten C Yip, Mercedes M Gonzalez ... Craig R Forest
    Patch-walking is a novel automated patch clamp approach for finding synaptic connections in brain tissue, yielding 80–92% more probed connections than traditional approaches.
    1. Computational and Systems Biology

    Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments

    Christopher A Jackson, Dayanne M Castro ... David Gresham
    Single cell expression data can be used to determine how regulatory transcription factors and target genes are connected, and is especially useful when studying transcription factors controlling heterogeneous cell states.
    1. Immunology and Inflammation

    A CD4+ T cell reference map delineates subtype-specific adaptation during acute and chronic viral infections

    Massimo Andreatta, Ariel Tjitropranoto ... Santiago J Carmona
    Description of the transcriptional and clonal landscape of virus-specific CD4+ T cells in acute and chronic viral infections, and a new reference map to interpret CD4 T cell diversity across tissues and biological models.

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