7,652 results found
    1. Structural Biology and Molecular Biophysics

    DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning

    Johannes Thomsen et al.
    An open-source user-friendly toolbox implementing machine learning for single-molecule FRET analysis enabling experts and non-experts to reproducibly provide dynamic structural biology insights.
    1. Structural Biology and Molecular Biophysics

    Top-down machine learning approach for high-throughput single-molecule analysis

    David S White et al.
    A new analysis algorithm (DISC) enables accurate analysis of data from high-throughput single-molecule paradigms and reveals a non-cooperative binding mechanism of cyclic nucleotide-binding domains from HCN ion channels.
    1. Structural Biology and Molecular Biophysics

    Modelling dynamics in protein crystal structures by ensemble refinement

    B Tom Burnley et al.
    A combination of molecular dynamics simulations and X-ray diffraction data has been used to construct more realistic models of proteins and to provide new insights into their interactions with other proteins and biomolecules.
    1. Physics of Living Systems

    Negative reciprocity, not ordered assembly, underlies the interaction of Sox2 and Oct4 on DNA

    John W Biddle et al.
    Rigorous reanalysis of single-molecule data yields evidence for energy expenditure in the interaction of transcription factors on DNA.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty et al.
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Massively multiplex single-molecule oligonucleosome footprinting

    Nour J Abdulhay et al.
    A novel single-molecule sequencing method reveals previously unappreciated heterogeneity in nucleosome positioning on individual chromatin fibers across the human genome.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Homology sensing via non-linear amplification of sequence-dependent pausing by RecQ helicase

    Yeonee Seol et al.
    The rate of DNA unwinding by RecQ helicases is dramatically modulated by the DNA duplex stability in a geometry-dependent manner, providing an intrinsic mechanism for suppressing illegitimate recombination.
    1. Structural Biology and Molecular Biophysics

    Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION

    Takanori Nakane et al.
    Multi-body refinement in RELION allows high-resolution reconstruction and visualisation of molecular motions in cryo-EM single-particle data sets with continuous forms of structural heterogeneity.
    1. Evolutionary Biology
    2. Neuroscience

    Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events

    David Ramos-Vicente et al.
    The animal phylogeny of glutamate receptors indicates that vertebrate types do not account for all receptor classes originated during evolution, neither are they the pinnacle of a linear evolutive process.
    1. Neuroscience

    Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity

    Isaac M Chiu et al.
    Molecular analysis paints a detailed picture of the distinctiveness and complexities of peripheral somatosensory neurons.

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