Integrated experimental-computational approaches were implemented to reveal the dynamic conformational landscape of a biologically relevant protein methyltransferase SETD8 for functional annotation.

Histone, PCNA, and DNA binding are essential for CAF-1 functions in preventing DNA damage during DNA replication in Schizosaccharomyces pombe, while its C-terminal domain specifies distinct cellular processes.

Precise control of the bacterial flagellar motor determines bacterial cell dispersal and bacteria-surface interactions.

Activation of the key regulator of cytokinesis, RhoA, involves an unexpected contribution by a RhoGAP domain.

Plasmodium parasites have repurposed the heme oxygenase scaffold from its canonical heme-degrading function to fulfill an essential and adaptive role in gene expression within the apicoplast organelle.

The mftG gene, present in the majority of mycofactocin gene clusters, encodes an oxidoreductase that facilitates ethanol utilization by reoxidation of mycofactocins and channeling electrons towards the respiratory chain.

A versatile acetylation-methylation switch at lysine 31 on the lateral surface of histone H4 contributes to chromatin structure in apicomplexan parasites.

OCT4 and SOX2 display partially independent activity to regulate chromatin accessibility, and highly dynamic activity of OCT4 is required throughout the cell cycle to maintain pluripotency enhancer accessibility.