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    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Topography and motion of acid-sensing ion channel intracellular domains

    Tyler Couch, Kyle D Berger ... David M Maclean
    The cytosolic elements of the acid-sensing ion channel move toward the plasma membrane when the channel is exposed to acidic conditions.
    1. Structural Biology and Molecular Biophysics

    Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

    Nadia Füllbrunn, Zehao Li ... Changjiang You
    The axial organization and dynamics of the HOPS complex at membrane surface are resolved by graphene-induced energy transfer with subnanometer resolution.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Protein-mediated RNA folding governs sequence-specific interactions between rotavirus genome segments

    Alexander Borodavka, Eric C Dykeman ... Don C Lamb
    In rotaviruses, the selective packaging of eleven distinct genomic RNA segments requires virus-encoded protein NSP2 to alter the RNA structures, facilitating their interactions with each other.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Identification of distinct pH- and zeaxanthin-dependent quenching in LHCSR3 from Chlamydomonas reinhardtii

    Julianne M Troiano, Federico Perozeni ... Gabriela S Schlau-Cohen
    Light-harvesting complex stress-related is a protein from photosynthetic green algae that prevents damage from sunlight via two distinct conformational processes, which protect against different timescales of solar fluctuations.
    1. Biochemistry and Chemical Biology

    Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins

    Víctor M Hernández-Rocamora, Natalia Baranova ... Waldemar Vollmer
    The synthesis of bacterial cell wall peptidoglycan was reconstituted in lipid bilayers and detected by a novel Förster resonance energy transfer real-time assay.
    1. Developmental Biology

    Extracellular interactions and ligand degradation shape the nodal morphogen gradient

    Yin Wang, Xi Wang ... Karuna Sampath
    Diffusivity, extracellular interactions of Nodal ligands with the receptors and inhibitors, and selective ligand destruction collectively shape the Nodal morphogen gradient.
    1. Structural Biology and Molecular Biophysics

    Dependence of nucleosome mechanical stability on DNA mismatches

    Thuy TM Ngo, Bailey Liu ... Taekjip Ha
    The mechanical stability of a nucleosome is enhanced upon the introduction of a single base pair mismatch that makes DNA more bendable, with implications on mismatch repair in vivo.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multi-step recognition of potential 5' splice sites by the Saccharomyces cerevisiae U1 snRNP

    Sarah R Hansen, David S White ... Aaron A Hoskins
    The yeast U1 snRNP recognizes multiple features of target RNAs to reversibly identify splicing-competent 5' splice sites.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Tunable molecular tension sensors reveal extension-based control of vinculin loading

    Andrew S LaCroix, Andrew D Lynch ... Brenton D Hoffman
    A quantitative understanding of molecular tension sensor function enables the production of unique sensors with desired mechanical properties as well as the ability to distinguish between protein force and protein deformation in mechanosensitive processes.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike

    Marco A Díaz-Salinas, Qi Li ... James B Munro
    The function of the SARS-CoV-2 spike is controlled by allosterically modulating the dynamics of the receptor-binding domain.