232 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Resolving dual binding conformations of cellulosome cohesin-dockerin complexes using single-molecule force spectroscopy

    Markus A Jobst et al.
    A single-molecule approach is able to discriminate the redundant binding conformations of cellulosomal dockerin based on differences in their mechanical properties.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-molecule force spectroscopy of protein-membrane interactions

    Lu Ma et al.
    A high-resolution method to quantify interactions between lipid bilayers and single proteins under controlled load is presented and applied to key proteins involved in membrane fusion and formation and maintenance of membrane contact sites.
    1. Physics of Living Systems

    Increasing evidence of mechanical force as a functional regulator in smooth muscle myosin light chain kinase

    Fabian Baumann et al.
    Atomic force microscopy based single-molecule force spectroscopy of smooth muscle myosin light chain kinase strongly indicates the existence of a mechanically triggerable activation pathway analogous to its well-established biochemical regulation pathway via calcium-loaded calmodulin.
    1. Structural Biology and Molecular Biophysics

    Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways

    Sukrit Suksombat et al.
    Single-molecule force and fluorescence spectroscopy reveal the structural states and dynamics of E. coli single-stranded DNA binding proteins and the energy landscape of the nucleo–protein complex.
    1. Structural Biology and Molecular Biophysics

    Single molecule compression reveals intra-protein forces drive cytotoxin pore formation

    Daniel M Czajkowsky et al.
    Compressive force spectroscopy of single molecules reveals that intra-protein forces underlie the long-distance coordination of structural changes within a cytotoxin during pore formation.
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis

    Ashutosh Pudasaini et al.
    In the plant circadian clock photoreceptor ZEITLUPE, evolutionarily selected residues distinguish photocycle kinetics and allosteric signal transduction pathways to permit proper circadian timing.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

    Caitlin N Spaulding et al.
    The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
    1. Cell Biology

    The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes

    Maria Benito-Jardón et al.
    The fibronectin synergy site is only required in vivo when forces exceed or αvβ3 integrin levels fall below certain thresholds.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

    Jixin Cui et al.
    Fam20A, a pseudokinase involved in the formation of tooth enamel, binds ATP in an unexpected orientation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins

    Aimin Yang et al.
    Legionella effector RavZ evades host autophagy by extracting LC3-PE from the membrane before deconjugation.

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