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    1. Structural Biology and Molecular Biophysics

    Structural dynamics of myosin 5 during processive motion revealed by interferometric scattering microscopy

    Joanna Andrecka et al.
    Single molecule imaging reveals how the molecular motor myosin 5 walks in a compass-like spinning motion along its actin track resulting in efficient, robust and unidirectional motion on the nanoscale.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin

    Sumanprava Giri et al.
    Origin recognition complex-associated (ORCA) is crucial for the stability of the Histone H3 lysine 9 methyltransferase megacomplex, which is essential for heterochromatin organization.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes

    Sang Hak Lee et al.
    Small probes show that most AMPA receptors are constrained near or in the synapses.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions

    Francesco M Piccolo et al.
    Single molecular imaging of MeCP2 at high spatial/temporal resolution identifies distinct structural domains contributing to its dynamic behaviors and chromatin interactions in live neurons.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

    Marvin E Tanenbaum et al.
    The motor domains of dynein are sufficient to crosslink microtubules and slide them antiparallel to each other.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair

    Maarten W Paul et al.
    Highly conserved C-terminal domains of the tumor suppressor BRCA2 are not essential for accumulation at damaged DNA but affect conformation and cell survival, implying roles beyond delivering strand-exchange protein RAD51.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops

    Christopher T Boughter et al.
    A new software developed for high-throughput antibody, T cell receptor, and MHC repertoire analysis uncovers neutrality of the binding interface and intramolecular crosstalk as distinguishing properties of polyreactive antibodies.
    1. Structural Biology and Molecular Biophysics

    Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer

    Van K Duesterberg et al.
    The combined use of optical trapping and single-molecule FRET permits the study of riboswitch structure formation and conformational dynamics at the same time.
    1. Cell Biology
    2. Physics of Living Systems

    Single-molecule turnover dynamics of actin and membrane coat proteins in clathrin-mediated endocytosis

    Michael M Lacy et al.
    The main proteins of clathrin-mediated endocytosis bind and unbind rapidly, continuously turning over about five times during the formation of an endocytic vesicle in yeast.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    High-throughput, single-particle tracking reveals nested membrane domains that dictate KRasG12D diffusion and trafficking

    Yerim Lee et al.
    The nanoscopic landscape of the membrane has a direct impact on the spatiotemporal, and likely also the signaling, dynamics of Ras proteins.