The molecular, cellular, and spatial heterogeneity of adult human spinal cord serve as an important resource to explore the mechanisms underlying spinal cord physiology and diseases.

Significant technical improvement in single-nucleus RNA-seq reveals distinct adipocyte subpopulations that respond differently to obesity, including those undergoing adaptive healthy expansion and others displaying severe dysfunction.

A cellular map of a deep-sea mussel gill unveils how distinct cell types collaborate to cultivate intracellular symbiotic bacteria, providing insights into host–symbiont interactions and environmental adaptation in bivalves.

Different subtypes of projection neurons in the mouse olfactory bulb are defined by distinct gene expression patterns and transcription factor networks.

RNA sequencing and genetic mouse models reveal that transcriptional changes to astrocytes in the developing cortex are not intrinsic but influenced by their environment and determine that expression of astrocyte synapse-regulating genes and neuronal synaptogenesis is modulated by ongoing astrocyte-neuron communication.

Adult neural stem cells differ in the types of neurons they generate according to their location and new territories and genes associated with dorsal and ventral neurogenic lineages in the adult mouse brain are revealed.

Spatially-resolved transcriptomics and single-nucleus RNA-sequencing are applied to the human locus coeruleus to characterize the gene expression profiles of norepinephrine (NE) neurons and other cell populations in this critical brain region, with all data made publicly available.

Using single nucleus RNA sequencing, a complete catalogue of cell types was determined for the mouse iris, and this information was used as a starting point to define the effects of pupil dilation on gene expression and on nuclear morphology.

A hybrid mouse/human model using mesenchymal progenitor cells reveals dynamics of human adipose tissue development and mechanisms that may enhance human adipose thermogenic capacity.

Gene expression and epigenetic profiling of defined cell types in the central nervous system of mouse, rat, and human reveals inter-species and inter-individual differences.