3,730 results found
    1. Computational and Systems Biology
    2. Genes and Chromosomes

    Single-cell analysis of transcription kinetics across the cell cycle

    Samuel O Skinner et al
    By properly accounting for gene copy number and cell-cycle effects, single cell snapshots of nascent and mature mRNA can be used to unveil the stochastic kinetics of gene activity.
    Short Report Updated
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    1. Biochemistry
    2. Biophysics and Structural Biology

    Cellular encoding of Cy dyes for single-molecule imaging

    Lilia Leisle et al
    Cyanine fluorophores are encoded as non-canonical amino acids to produce functional proteins in cell-free translation systems and live cells for single-molecule imaging.
    Tools and Resources Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Biophysics and Structural Biology

    A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

    Sunbin Liu et al
    Structural and functional analyses show how the spliceosomal Prp3 protein concomitantly binds double- and single- stranded regions in U4/U6 di-snRNAs and serves to stabilize the U4/U6•U5 tri-snRNP for splicing.
    Research Article Updated
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    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    Single-molecule tracking of the transcription cycle by sub-second RNA detection

    Zhengjian Zhang et al
    A new technique called fastFISH enables nearly real-time and stoichiometric detection of nascent RNA and the tracking of individual stages of transcription at the level of single-molecules.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Ecology
    2. Microbiology and Infectious Disease

    Ecology and evolution of viruses infecting uncultivated SUP05 bacteria as revealed by single-cell- and meta-genomics

    Simon Roux et al
    Single-cell amplified genome sequencing uncovers virus-host interactions in uncultivated sulfur-oxidizing bacteria with relevance to coupled biogeochemical cycling in marine oxygen minimum zones.
    Research Article Updated
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    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture

    Hernán Morales-Navarrete et al
    MotionTracking is freely available software that can generate multi-scale geometrical models of mammalian tissue and perform quantitative analysis of tissue architecture.
    Tools and Resources Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology

    Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways

    Sukrit Suksombat et al
    Single-molecule force and fluorescence spectroscopy reveal the structural states and dynamics of E. coli single-stranded DNA binding proteins and the energy landscape of the nucleo–protein complex.
    Research Article Updated
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    1. Biochemistry
    2. Biophysics and Structural Biology

    Resolving dual binding conformations of cellulosome cohesin-dockerin complexes using single-molecule force spectroscopy

    Markus A Jobst et al
    A single-molecule approach is able to discriminate the redundant binding conformations of cellulosomal dockerin based on differences in their mechanical properties.
    Research Article Updated
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    1. Biochemistry
    2. Genomics and Evolutionary Biology

    Circularization restores signal recognition particle RNA functionality in Thermoproteus

    André Plagens et al
    Archaea can contain permuted versions of the universal signal recognition particle RNA, which require a moonlighting activity of the tRNA splicing machinery to generate functional circular RNAs.
    Short Report Updated
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    1. Biophysics and Structural Biology
    2. Cell Biology

    Real-time observation of signal recognition particle binding to actively translating ribosomes

    Thomas R Noriega et al
    The signal recognition particle only stably engages translating ribosome nascent-chain complexes exposing a functional signal sequence.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf

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