154 results found
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Bayesian inference of kinetic schemes for ion channels by Kalman filtering

    Jan L Münch, Fabian Paul ... Klaus Benndorf
    For analyzing time-dependent patch-clamp or patch-clamp fluorometry data of ion channels in terms of Markovian models, the superiority of Bayesian filtering with respect to traditional deterministic approaches is demonstrated enabling more reliable quantification of the parameters.
    1. Neuroscience

    A unifying mechanism governing inter-brain neural relationship during social interactions

    Wujie Zhang, Maimon C Rose, Michael M Yartsev
    Experiments and modeling suggest that a mechanism involving positive and negative feedback can explain the relationship between the neural activity of socially interacting bats.
    1. Neuroscience

    Cellular and neurochemical basis of sleep stages in the thalamocortical network

    Giri P Krishnan, Sylvain Chauvette ... Maxim Bazhenov
    A computational model of the thalamocortical network explains sleep stages by the coordinated variations in the level of neuromodulators and predicts differences of sleep pattern in human, cat and mouse recordings.
    1. Neuroscience

    An inhibitory gate for state transition in cortex

    Stefano Zucca, Giulia D’Urso ... Tommaso Fellin
    Two major subtypes of cortical interneurons, the PV and the SST positive cells, causally contribute to the regulation of large-scale state transitions in the cortex.
    1. Neuroscience

    Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves

    Miriam Schwalm, Florian Schmid ... Albrecht Stroh
    Locally recorded calcium events related to slow wave activity show a global cortical fMRI BOLD correlate, establishing a direct relation between a basic neurophysiological signal and the macroscopic perspective of pre-clinical fMRI.
    1. Neuroscience

    Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

    Domenico Pimpinella, Valentina Mastrorilli ... Marilena Griguoli
    Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
    1. Neuroscience

    Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1

    J Elliott Robinson, Gerard M Coughlin ... Viviana Gradinaru
    Heterozygous Nf1 knockout mice exhibit distinct dopaminergic phenotypes in vivo, as revealed by the genetically encoded dopamine sensor dLight1, patch clamp electrophysiology, optogenetics, and novel viral tools for morphological analysis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP

    David Massa López, Melanie Thelen ... Markus Damme
    The so far uncharacterized lysosomal transporter protein MFSD1 is essential for liver homeostasis and needs the highly glycosylated GLMP protein as an accessory subunit for stability.
    1. Immunology and Inflammation

    Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help

    Ting-ting Zhang, David G Gonzalez ... Ann M Haberman
    CD40 signaling is necessary to generate the immediate precursors of GC B cells, transition to the BCL6hi follicular state is promoted by a regional and transient diminution of T cell help.
    1. Neuroscience

    Active tactile discrimination is coupled with and modulated by the cardiac cycle

    Alejandro Galvez-Pol, Pavandeep Virdee ... James Kilner
    Human subjects actively adjust the acquisition of sense data based on how their bodily cycles alter their senses, i.e., sensing tactile stimuli for longer periods when concurrent physiological signals are present vs. sensing for shorter periods when these are quiescent.

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