Double-stranded precursors of siRNAs involved in RNA-directed DNA methylation have initiating sequences and overhangs imparted by the RNA polymerases that synthesize them, programming alternative dicing reactions that diversify the siRNA pool.
The nerve growth-repellent activity that generates spinal nerve repeat-patterning in birds and mammals is identified at the molecular level, and a similar system is revealed in adult brain grey matter.
Global brain transduction of the instability-prone Mecp2 transgene by systemic AAV-PHP.eB administration is safe and effective in protecting male and female Mecp2 mutant mice from the Rett syndrome disease phenotype.
Quantitative time-resolved crosslinking mass spectrometry is developed to monitor protein interactions and dynamics inside molecular condensates and used to identify misfolding of the RNA-binding domain of FUS as a key driver of condensate-aging.
In natural pathogen populations opportunities for sexual outcrossing vary, leading to spatial variation in genetic diversity and between-season survival.
Siyu Serena Ding, Linus J Schumacher ... André EX Brown
Two seemingly distinct behaviors in social C. elegans worms, namely aggregating into groups and swarming over food, are driven by the same underlying mechanisms.
Georgia M Alexander, Logan Y Brown ... Serena M Dudek
Hippocampal area CA2 controls low gamma and ripple oscillations, brain waves known to be impaired in schizophrenia, implicating this important brain region in cognition.
Giuseppina Porciello, Alessandro Monti ... Salvatore Maria Aglioti
Direct measures of inner gastrointestinal signals via ingestible capsules highlight the role of stomach pH in shaping human feelings of disgust, fear and happiness.
