4,197 results found
    1. Cell Biology

    The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex

    Gunther Hollopeter et al.
    Endocytosis is triggered by membrane-associated proteins that transform the clathrin adaptor into an active complex.
    1. Biochemistry and Chemical Biology

    A toolkit for studying cell surface shedding of diverse transmembrane receptors

    Amanda N Hayward et al.
    The modularity and unequivocal input/response of Notch signaling are harnessed to measure cell-surface shedding of diverse transmembrane receptors to identify new proteolytic switches and detect modulation of proteolysis by therapeutics.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Pi-Pi contacts are an overlooked protein feature relevant to phase separation

    Robert McCoy Vernon et al.
    Statistics on the frequencies of pi interactions in folded protein structures enable successful prediction of intrinsically disordered protein phase separation, with clear implications for a physical understanding of cellular organization.
    1. Cell Biology

    Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

    Ciara M Gallagher et al.
    Ceapins enable selective pharmacological inhibition of the cytoprotective transcriptional response to endoplasmic reticulum stress through ATF6α without affecting other branches of the unfolded protein response.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Learning protein constitutive motifs from sequence data

    Jérôme Tubiana et al.
    A new machine-learning toolbox unveils coevolutionary protein motifs related to structure, function, and phylogeny from sequence information only.
    1. Cancer Biology

    KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

    Sawan Kumar Jha et al.
    Both VEGF-C and VEGF-D can be activated by KLK3/PSA and Cathepsin D, producing two novel VEGF-C forms and the known VEGFR-2-specific form of VEGF-D.
    1. Immunology and Inflammation

    The HIV-1 latent reservoir is largely sensitive to circulating T cells

    Joanna A Warren et al.
    HIV-specific T cells remain detectable for years in HIV-infected individuals on antiretroviral therapy and importantly, mostly (68%) recognize HIV viruses that have the capacity to rebound following treatment interruption.
    1. Cell Biology
    2. Developmental Biology

    HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans

    Maxime J Kinet et al.
    A pathway controlling non-apoptotic developmental cell death engages non-canonical death-promoting activities of the stress factor HSF-1, which, in turn, activates specific components of the ubiquitin-mediated degradation machinery.
    1. Neuroscience

    Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity

    Oleksandr Yagensky et al.
    Increased levels of brain Hebp1 starting from the presymptomatic stage of Alzheimer’s disease contributes to progressive neuronal loss by triggering mitochondrial-dependent apoptosis in neurons exposed to elevated heme.
    1. Immunology and Inflammation

    RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

    Kirsteen M Tullett et al.
    Dendritic cell recognition and processing of antigens from dead cells, utilising the Clec9A-damage recognition receptor, is controlled by a novel RNF41-ubiquitin-mediated regulatory pathway.

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