The analytic theory establishes the general principles of synaptic transmission, enables extraction of microscopic parameters of synaptic fusion machinery from experiments, and links molecular constituents to synaptic function.
Ankur Sinha, Padraig Gleeson ... Robin Angus Silver
The NeuroML model description language, with its extensive software ecosystem, supports researchers in the development of FAIR, data-driven, biologically detailed models of neural systems.
A novel role of the mitochondrial BKCa channel involves the metabolic reprogramming of breast cancer cells, facilitating their unrestricted proliferation and O2-independence, which is also of potential clinical relevance.
Ribosomal proteins Rps27 (eS27) and Rps27l (eS27L) are an ancient pair of duplicated genes that encode functionally interchangeable proteins, yet have been evolutionarily retained because both copies are necessary to achieve protein expression across cell types.
Gareth W Fearnley, Katherine A Young ... Hayley J Sharpe
Systematic proteomic approaches identify several cell junction regulators as substrates for the homophilic receptor tyrosine phosphatase PTPRK and implicate its pseudophosphatase domain in substrate recognition.
Inverse gradients of cell ingression and division in the epiblast allow the bipotent progenitors in the anterior streak to become the main progenitors for posterior axis formation from the tail bud.
Joeri BG van Wijngaarden, Susanne S Babl, Hiroshi T Ito
An extended border coding circuit across the entorhinal and retrosplenial cortex incorporates self-referenced and viewpoint-invariant boundary information to guide navigation behavior.
The collinear activation of a subset of posterior Hox genes is responsible for establishing a Wnt/T activity gradient that is required to generate the complete body axis, and hence the full set of segments within a vertebrate embryo.
Kishore R Mosaliganti, Ian A Swinburne ... Sean G Megason
Size regulation of the otic vesicle, the progenitor of the inner ear, is mediated by mechanical feedback involving fluid influx, hydraulic pressure, and tissue mechanics.