72 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

    Qixuan Wang et al.
    Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.
    1. Ecology

    Extinction risk and conservation of the world’s sharks and rays

    Nicholas K Dulvy et al.
    One-quarter of the Chondrichthyes have an elevated risk of extinction, mainly as a result of overfishing.
    1. Cell Biology
    2. Developmental Biology

    Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions

    Arul Subramanian, Thomas F Schilling
    Functional attachments between muscles and tendons require pentameric Thrombospondin-4, revealing novel roles both as an integrin ligand and extracellular matrix scaffold.
    1. Structural Biology and Molecular Biophysics

    Specific Eph receptor-cytoplasmic effector signaling mediated by SAM–SAM domain interactions

    Yue Wang et al.
    Comparative structural studies reveal how the cytoplasmic tails of Eph receptors can differentiate different downstream target proteins via highly specific SAM–SAM domain interactions.
    1. Computational and Systems Biology
    2. Developmental Biology

    Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning

    Autumn P Pomreinke et al.
    Patterning of the dorsal-ventral axis in zebrafish is mediated by a graded source-sink mechanism in which diffusing BMP, produced from a ventrally biased source, is inhibited by dorsally-produced chordin.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height

    Michael Guo et al.
    Epigenetic profiling of femoral growth plate chondrocytes helps whittle-down GWAS height variants to fewer putative functional variants.
    1. Developmental Biology

    Local cell interactions and self-amplifying individual cell ingression drive amniote gastrulation

    Octavian Voiculescu et al.
    A combination of two local cell interactions, intercalation and ingression amplified by a community-effect, is sufficient to explain the global movements of amniote gastrulation.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors

    Silvia Peluso et al.
    FGF signalling is responsible for priming the developmental enhancer ZRS across the distal limb mesenchyme during development, allowing ETS factors to modulate its activity through balancing histone acetylation.
    1. Developmental Biology
    2. Neuroscience

    Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators

    Wilson Mena et al.
    The response of the peptidergic neurons that control a stereotyped behavior depends on the actions of a triggering neuropeptide, downstream neuropeptides and GABA inhibitory influences.
    1. Neuroscience

    Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice

    Li Fan et al.
    A general cytoplasmic signaling mechanism for the novel functions of diverse alpha protocadherins in cortical neuron migration and actin cytoskeletal dynamics as well as dendrite morphogenesis in the brain.

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