11 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Functional divergence of paralogous transcription factors supported the evolution of biomineralization in echinoderms

    Jian Ming Khor, Charles A Ettensohn
    A gene duplication event has permitted the functional specialization of a homeodomain transcription factor through changes in exon-intron organization and these changes have supported the evolution of a major, phylum-level morphological novelty.
    1. Developmental Biology
    2. Evolutionary Biology

    Development: Transforming a transcription factor

    Robert D Burke
    A transcription factor that regulates skeleton formation in sea urchin embryos has evolved a new domain that is essential for this process.
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    1. Ecology

    A SLC4 family bicarbonate transporter is critical for intracellular pH regulation and biomineralization in sea urchin embryos

    Marian Y Hu et al.
    Cellular carbon accumulation systems are a fundamental prerequisite for biomineralization to stabilize pH and to supply inorganic carbon for CaCO3 precipitation under changing environmental conditions.
    1. Developmental Biology

    Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis

    Joana Esteves de Lima et al.
    A novel mechanism links mechanical signals with the molecular YAP and NOTCH signals operating during developmental myogenesis.
    1. Cell Biology
    2. Developmental Biology

    Early asymmetric cues triggering the dorsal/ventral gene regulatory network of the sea urchin embryo

    Vincenzo Cavalieri, Giovanni Spinelli
    During early embryogenesis of the sea urchin, asymmetrical positioning of the dorsal/ventral organizer relies upon the suppression of organizer activities in dorsal blastomeres by the Hbox12 homeodomain-containing repressor.
    1. Human Biology and Medicine

    Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

    John B Lees-Shepard et al.
    Daily palovarotene treatment reduces pathogenic expansion of fibro/adipogenic progenitors but results in long bone growth plate loss and overgrowths of synovial cartilage in juvenile mice.
    1. Computational and Systems Biology
    2. Developmental Biology

    Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways

    Harish N Vasudevan et al.
    PDGF and FGF signal via distinct intracellular pathways to confer different cellular outcomes during craniofacial development.
    1. Cell Biology

    Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function

    Laura Vuolo et al.
    Genetic knock-outs of the dynein-2 intermediate chains reveals that both are essential for correct cilia function and transition zone organization, but play different functions in the assembly of dynein-2 motor and in primary cilia formation.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Protein sequences bound to mineral surfaces persist into deep time

    Beatrice Demarchi et al.
    A chemically unstable ostrich eggshell peptide survives for at least 3.8 million years at the equator, stabilized by strong mineral interactions.
    1. Cell Biology
    2. Developmental Biology

    Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche

    Valerie S Salazar et al.
    A periosteal Bmp2 signaling center couples bone length to bone width during development and must be reactivated by clinical bone anabolic therapies to reduce fracture risk and accelerate fracture repair.

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