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    1. Neuroscience

    Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels

    Derya Sargin et al.
    Serotonin neurons in chronically isolated mice become less responsive to excitatory stimulation, but inhibiting a distinctive calcium-activated potassium channel can restore both neuronal activity and behavior.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

    Nima Etemadi et al.
    Intrinsic defects in keratinocytes can cause skin inflammation through excessive cell death and production of inflammatory molecules.
    1. Cell Biology

    Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery

    Daniel G Booth et al.
    The mitotic chromosome periphery is organised by the PP1 binding protein Ki-67 and contributes to nucleolar re-activation upon mitotic exit.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

    Sushama Sivakumar et al.
    Microtubule binding by the Spindle and Kinetochore Associated (Ska) complex concentrates protein phosphatase 1 at metaphase kinetochores to overcome the spindle checkpoint thus driving anaphase onset and mitotic exit.
    1. Cell Biology
    2. Human Biology and Medicine

    Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

    Christopher A Natale et al.
    Two receptors have been identified that can be targeted in melanocytes with selective small molecule agonists to modulate human skin color.
    1. Immunology and Inflammation

    Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair

    Olga Barreiro et al.
    A new type of skin perivascular macrophages with extramedullary origin, access to blood and exclusive anti-inflammatory reparative properties has been characterized.
    1. Microbiology and Infectious Disease

    Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

    Christopher Petro et al.
    An attenuated Herpes simplex type 2 virus deleted in glycoprotein D can be used as an effective vaccine to provide robust transferable humoral immunity and complete protection in murine intravaginal and skin infection models.
    1. Physics of Living Systems

    Somatosensory neurons integrate the geometry of skin deformation and mechanotransduction channels to shape touch sensing

    Alessandro Sanzeni et al.
    Nonlinear elasticity of skin tissues and somatosensory neural responses are combined to predict and test C. elegans processing of touch stimuli and modifications due to changes in the body mechanics.
    1. Developmental Biology

    An RNAi screen unravels the complexities of Rho GTPase networks in skin morphogenesis

    Melanie Laurin et al.
    An unprecedented large-scale screen in mice for morphogenetic regulators of tissue development provides major new insights into the roles of Rho GTPases in diverse array of skin developmental processes.