67 results found
    1. Cancer Biology
    2. Cell Biology

    TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2

    Amy T Ku et al.
    Overexpression of TCF7L1 overrides oncogenic Ras-induced senescence, induces cell migration, and promotes growth of skin squamous cell carcinoma independently of its interaction with β-catenin.
    1. Stem Cells and Regenerative Medicine

    ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas

    Hanseul Yang et al.
    Transcription factors of the ETS family govern a cohort of key cancer-associated regulators of malignancy in squamous cell carcinomas.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

    Heather A McCauley et al.
    A new mechanism connects the loss of TGFβ signaling with invasion and metastasis in highly malignant transition zone tumors.
    1. Cancer Biology

    BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

    Harina Vin et al.
    The cancer drug vemurafenib has potent off-target effects on JNK signaling that contribute to the development of squamous cell carcinomas in humans and in mice.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    YAP drives cutaneous squamous cell carcinoma formation and progression

    Zoé Vincent-Mistiaen et al.
    High levels of nuclear YAP are sufficient to drive squamous cell carincoma formation and frequently also drive progression to spindle cell carcinoma by promoting epithelial-to-mesenchymal transition after tissue damage.
    1. Developmental Biology

    Type XVII collagen coordinates proliferation in the interfollicular epidermis

    Mika Watanabe et al.
    Type XVII collagen, a transmembranous protein in basal keratinocytes, suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis.
    1. Cancer Biology

    Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

    SungEun Kim et al.
    Pharmacologic inhibition of DNA methylation restrains the growth of urothelial carcinoma by subtype conversion through heightened stromal Hedgehog pathway activity.
    1. Cancer Biology
    2. Developmental Biology

    Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ

    Lorenzo Rinaldi et al.
    Dnmt3a and Dnmt3b are dispensable for epidermal homeostasis but act as potent tumor suppressors regarding skin squamous tumorigenesis.
    1. Developmental Biology
    2. Cancer Biology

    MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells

    Kent Riemondy et al.
    Inhibition of microRNA-203 by oncogenic HRas mutations promotes skin cancer initiation.
    1. Stem Cells and Regenerative Medicine

    Philosophy of Biology: Towards a classification of stem cells

    Lucie Laplane, Eric Solary
    The occurrence, progression and treatment of cancer may be linked to changes in the nature of stemness.

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