121 results found
    1. Neuroscience

    Rotating waves during human sleep spindles organize global patterns of activity that repeat precisely through the night

    Lyle Muller et al.
    A phase-based analysis reveals wave-like spatiotemporal organization of the human sleep spindle, a brain oscillation critical to sleep-dependent memory consolidation, and elucidates its role in coordinating activity of neural networks distributed across the cortex.
    1. Neuroscience

    Thalamic reticular control of local sleep in mouse sensory cortex

    Laura MJ Fernandez et al.
    Local cortical sleep features arise subcortically due to heterogeneous burst discharge in neurons of a sleep rhythm pacemaker previously thought to act uniformly.
    1. Neuroscience

    Cellular and neurochemical basis of sleep stages in the thalamocortical network

    Giri P Krishnan et al.
    A computational model of the thalamocortical network explains sleep stages by the coordinated variations in the level of neuromodulators and predicts differences of sleep pattern in human, cat and mouse recordings.
    1. Neuroscience

    A nap to recap or how reward regulates hippocampal-prefrontal memory networks during daytime sleep in humans

    Kinga Igloi et al.
    Sleep plays a critical role in the selectivity of memory by promoting the retention of important memories at the expense of less relevant ones.
    1. Neuroscience

    Developmental Neuroscience: Catching a wave

    P Michelle Fogerson, John R Huguenard
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    1. Cell Biology

    Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation

    Duccio Conti et al.
    Human chromosome-microtubule attachments are stabilised by Astrin-mediated dynamic delivery of PP1 phosphatase to the attachment site, which ensures the normal segregation of chromosomes.
    1. Cell Biology
    2. Neuroscience

    Neurotrophins induce fission of mitochondria along embryonic sensory axons

    Lorena Armijo-Weingart et al.
    Induction of the fission of mitochondria-populating sensory axons is shown to be a novel biological action of neurotrophins.
    1. Neuroscience

    Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome

    Irene Bolea et al.
    Glutamatergic brainstem neurons drive motor and respiratory deficits, and GABAergic basal ganglia neurons cause hypothermia and fatal epileptic events, in a model of mitochondrial disease.
    1. Cell Biology

    PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall

    Tyler Chistopher Moyer, Andrew Jon Holland
    Cell biological, biochemical, and genetic analyses reveal that PLK4 controls two different phospho-dependent binding interactions that act together to promote procentriole assembly.
    1. Neuroscience

    The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy

    Laura A Ewell et al.
    A novel framework for separating normal and pathological high-frequency oscillations in animals with epilepsy uncovers new mechanisms for impaired hippocampal network function.

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