1,355 results found
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

    Flora S Groothuizen et al.
    Visualization of the sliding clamp in DNA mismatch repair shows how a transient complex is activated.
    1. Structural Biology and Molecular Biophysics

    cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ

    Rafael Fernandez-Leiro et al.
    Structures of the replicative DNA polymerase Pol IIIα, the DNA sliding clamp, the proofreading exonuclease, and the processivity switch Tau (τ) suggest a mechanism for quick release during lagging strand synthesis.
    1. Biochemistry and Chemical Biology

    Stepwise assembly of the human replicative polymerase holoenzyme

    Mark Hedglin et al.
    Fluorescence resonance energy transfer has been used to explore the interactions between DNA polymerases, sliding clamps and clamp loaders as DNA is replicated in human cells.
    1. Neuroscience

    Synaptic representation of locomotion in single cerebellar granule cells

    Kate Powell et al.
    The first patch-clamp recordings from single cerebellar granule cells during locomotion reveal that the entire step sequence can be predicted from both excitatory synaptic input and output spikes from a single neuron.
    1. Chromosomes and Gene Expression

    The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress

    Takeshi Wakida et al.
    Minimizing anti-proliferation signaling from DNA damage detection machinery is the tactic for the cells to drive proliferation under genotoxic environment, and the function is exerted by Polo-Like-Kinase1 that is frequently over-expressed in cancer cells.
    1. Chromosomes and Gene Expression

    A CTP-dependent gating mechanism enables ParB spreading on DNA

    Adam SB Jalal et al.
    A structural and biochemical approach shows that CTP binding and hydrolysis regulate nucleation, spreading, and recycling of a chromosome segregation protein ParB.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis

    Gengjing Zhao et al.
    Competing DNA polymerases at the DNA sliding clamp are revealed by single-molecule co-localization studies.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS

    Francisco de Asis Balaguer et al.
    Single-molecule methods reveal that cytidine triphosphate promotes DNA condensation specifically at bacterial centromeres by facilitating one-dimensional diffusion of ParB from parS sites.
    1. Neuroscience

    Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory

    Paul Pfeiffer et al.
    Independently gating ion channels typically act fast within milliseconds, but cooperative interactions within a cluster of channels allow for a memory of previous electrical activity for several seconds.
    1. Computational and Systems Biology
    2. Neuroscience

    Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons

    Philipe RF Mendonça et al.
    A-type potassium conductances influence the distinctive firing behaviour of irregular-spiking interneurons.

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