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    1. Cell Biology
    2. Developmental Biology

    Dual role for Jumu in the control of hematopoietic progenitors in the Drosophila lymph gland

    Yangguang Hao, Li Hua Jin
    Jumu is required for the proper differentiation of prohemocytes and the proliferation and location of PSC cells.
    1. Developmental Biology

    Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

    Wilma Tixi, Maricela Maldonado ... Hung Ping Shih
    ECM-Itgb1 signaling and cell-cell adhesion are pivotal and coordinate together to regulate pancreatic islet aggregation, architecture, and functional maturation during development.
    1. Developmental Biology

    Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy

    Tai-Heng Chen, Jun-An Chen
    Summary review of microRNA roles during motor neuron generation and degeneration.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth

    Baisakhi Mondal, Hongjian Jin ... Hans-Martin Herz
    Identification of the underlying molecular gene-regulatory mechanisms by which the histone deacetylase complex MiDAC controls neurite outgrowth.
    1. Developmental Biology
    2. Neuroscience

    Spatiotemporal changes in Netrin/Dscam1 signaling dictate axonal projection direction in Drosophila small ventral lateral clock neurons

    Jingjing Liu, Yuedong Wang ... Yao Tian
    Dynamic local microenvironments in Drosophila facilitate axonal projection direction transitions in the absence of clear landmarks.
    1. Neuroscience

    Netrin-1 regulates the balance of synaptic glutamate signaling in the adult ventral tegmental area

    Marcella M Cline, Barbara Juarez ... Larry S Zweifel
    Genetic analysis of Ntn1 in adult mouse midbrain neurons reveals its function in maintaining excitatory synapses, loss of Ntn1 function in inhibitory neurons is significantly detrimental to mesolimbic system function.
    1. Developmental Biology

    Intrinsic control of muscle attachment sites matching

    Alexandre Carayon, Laetitia Bataillé ... Jean-Louis Frendo
    Making a link between deletion of transcription cis-regulatory elements by CrispR/Cas9, obtention of mutants with single muscle morphology defects and their impact on locomotion.
    1. Neuroscience

    NOVA2-mediated RNA regulation is required for axonal pathfinding during development

    Yuhki Saito, Soledad Miranda-Rottmann ... Robert B Darnell
    The RNA-binding protein NOVA2 coordinately regulates the alternative splicing of key components in axon guidance and outgrowth pathways, with severe functional consequences.
    1. Cancer Biology
    2. Genetics and Genomics

    Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors

    Minsu Kang, Hee Young Na ... Jong Seok Lee
    As the first to track clonal evolution from precancerous to metastatic lesions in gallbladder cancer patients, spatial and temporal analyses reveal how subclonal diversity in precancerous stage changes toward the metastasis, which help early detection and effective treatment of cancer.
    1. Developmental Biology
    2. Neuroscience

    NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord

    Janelle C Leggere, Yuhki Saito ... Zhe Chen
    Alternative splicing of the Dcc gene, which is controlled by the NOVA RNA-binding proteins, is crucial during neuronal migration and axon guidance.