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    1. Neuroscience

    Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves

    Miriam Schwalm et al.
    Locally recorded calcium events related to slow wave activity show a global cortical fMRI BOLD correlate, establishing a direct relation between a basic neurophysiological signal and the macroscopic perspective of pre-clinical fMRI.
    1. Neuroscience

    Cerebellar climbing fibers encode expected reward size

    Noga Larry et al.
    Electrophysiological recordings in monkeys reveal that cerebellar complex spikes encode future reward size when reward information is first made available, but not during reward delivery or smooth pursuit eye movement.
    1. Cell Biology
    2. Plant Biology

    Two mechanisms regulate directional cell growth in Arabidopsis lateral roots

    Charlotte Kirchhelle et al.
    In lateral roots, cells employ a novel pathway to cell edges to control directional growth, which acts independently of the leading paradigm of oriented deposition of cellulose microfibrils at faces.
    1. Neuroscience

    CaImAn an open source tool for scalable calcium imaging data analysis

    Andrea Giovannucci et al.
    CaImAn is an open-software package that equips the neuroscience community with a set of turnkey, fast and scalable solutions to pre-processing problems arising in single cell calcium imaging data analysis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

    Nicolas Altemose et al.
    In humans, specific sequence features can predict whether meiotic recombination occurs at sites bound by the protein PRDM9, whose DNA-binding zinc-finger domain can unexpectedly bind to gene promoters and to other copies of PRDM9.
    1. Microbiology and Infectious Disease

    Microbiota functional activity biosensors for characterizing nutrient metabolism in vivo

    Darryl A Wesener et al.
    A method has been developed to characterize the expressed biochemical activities of gut microbial communities using retrievable, microscopic, fluorescent-labeled glass beads containing chemically bound surface biomolecules.
    1. Neuroscience

    Cerebellar learning using perturbations

    Guy Bouvier et al.
    A proposal for a complete cellular/network implementation of trial-and-error motor learning in the olivo-cerebellar system.
    1. Neuroscience

    Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency

    Richard B Crouse et al.
    The release of acetylcholine in the basolateral amygdala is precisely timed to salient events during reward learning but has long-lasting effects that potentiate learning of cue-reward contingencies.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genetic factors of bilaterian evolution

    Peter Heger et al.
    Advanced orthology clustering of bilaterian and non-bilaterian sequences identifies 157 bilaterian-specific genes which are linked to key morphological features of this animal group.
    1. Cell Biology
    2. Computational and Systems Biology

    Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

    Jakub Tomek et al.
    A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.