488 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo

    Megan L Martik, David R McClay
    The gene regulatory network controlling directed cell migration in a sea urchin is strikingly similar to a sub-circuit for eye development in Drosophila, suggesting that ancient systems-level controls may be adapted for diverse functions in different animals.
    1. Developmental Biology

    The evolutionary modifications of a GoLoco motif in the AGS protein facilitate micromere formation in the sea urchin embryo

    Natsuko Emura, Florence DM Wavreil ... Mamiko Yajima
    Activator of G-protein signaling C-terminus serves as a variable element to induce asymmetric cell division, facilitating developmental diversity among species.
    1. Neuroscience

    Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI

    Miriam Menzel, David Gräßel ... Marios Georgiadis
    Light and X-ray scattering on the same primate and human brain samples cross-validate each other and enable accurate mapping of axonal trajectories in regions with uni- and multi-directional nerve fibers, which can be used to validate diffusion MRI.
    1. Cell Biology

    Apical annuli are specialised sites of post-invasion secretion of dense granules in Toxoplasma

    Sara Chelaghma, Huiling Ke ... Ross F Waller
    Apicomplexan parasites secrete proteins to manipulate their hosts from sub-apical openings in their cell pellicle that are distinct from the apical complex from where invasion factors are secreted.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Three-dimensional electron crystallography of protein microcrystals

    Dan Shi, Brent L Nannenga ... Tamir Gonen
    A new electron diffraction technique called MicroED allows protein structures to be determined from three-dimensional microcrystals.
    1. Microbiology and Infectious Disease

    Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration

    Malgorzata Broncel, Caia Dominicus ... Moritz Treeck
    Myristoylation of a secreted protein, identified in a global myristoylation analysis of the eukaryotic parasite Toxoplasma gondii, is important for host cell invasion.
    1. Cell Biology
    2. Developmental Biology

    Early asymmetric cues triggering the dorsal/ventral gene regulatory network of the sea urchin embryo

    Vincenzo Cavalieri, Giovanni Spinelli
    During early embryogenesis of the sea urchin, asymmetrical positioning of the dorsal/ventral organizer relies upon the suppression of organizer activities in dorsal blastomeres by the Hbox12 homeodomain-containing repressor.
    1. Developmental Biology
    2. Evolutionary Biology

    Functional divergence of paralogous transcription factors supported the evolution of biomineralization in echinoderms

    Jian Ming Khor, Charles A Ettensohn
    A gene duplication event has permitted the functional specialization of a homeodomain transcription factor through changes in exon-intron organization and these changes have supported the evolution of a major, phylum-level morphological novelty.
    1. Neuroscience

    Basal ganglia output coding - entopeduncular nucleus - of contextual kinematics and reward in the freely moving mouse

    Anil K Verma-Rodríguez, Josué O Ramírez-Jarquín ... Fatuel Tecuapetla
    Revised
    Reviewed Preprint v2
    Updated
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    1. Physics of Living Systems

    Interplay of surface interaction and magnetic torque in single-cell motion of magnetotactic bacteria in microfluidic confinement

    Agnese Codutti, Mohammad A Charsooghi ... Stefan Klumpp
    Confined magnetotactic bacteria exhibit circling and U-turn trajectories explained by a competition of alignment with a magnetic field and alignment along the confining walls as well as considerable cell-to-cell heterogeneity.

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