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Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?

A new optical approach reveals dynamics of ground reaction forces in Drosophila larvae and opens new avenues for studying the biomechanics of movement in small animals.

Lineage tracing at single-cell resolution reveals the presence of mesoteloblasts, the embryonic origin of mesodermal growth zone cells, and diverse cell cycling patterns of these lineages in the 'Polychaete' annelid Platynereis.

Comprehensive characterization of kinase-dependent phosphorylation in the human pathogen Toxoplasma gondii identifies a trafficking adaptor complex required for virulence factor secretion and infection.

A method was developed to non-invasively and simultaneously track individual action-potentials propagating across multiple branches of identified neurons in neocortical cultures.

Gamma-band synchronization behavior in area V1 was predicted by weakly coupled oscillator principles.

Ultrastructure expansion microscopy unlocks new fundamental cell biology of malaria parasites, providing new insights into processes including establishment of cell polarity, organelle biogenesis, and organelle fission.

Volumetric trans-scale imaging with a subcellular resolution across a wide field-of-view of 1.5 × 1.0 cm² has been realized, facilitating the analysis of cellular dynamics during embryogenesis and brain function.

Kipferl, a ZAD zinc finger protein from Drosophila, determines the chromatin binding specificity of the heterochromatin protein variant Rhino, defining piRNA clusters and preventing Rhino sequestration by selfish Satellite repeats.

Unsupervised machine learning on the ultrastructure and shape of cells in volume electron microscopy yields a compact representation of cellular morphology that complements genetics-based cell type characterisation.