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Genetics and Genomics
is a maternal effect gene required for genomic imprinting
Iromi Wanigasuriya et al.
Imprinted gene expression is set up during a critical window of early embryonic development, by the translation of parental imprints by oocyte-supplied Smchd1 into allele-specific gene silencing.
A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain
Lihong Zhan et al.
A hidden population of microglial progenitors with distinct transcriptomic signatures are among homeostatic microglia in adult mouse brain.
The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model
Jaime N Wertman et al.
L-mimosine and dopamine protect against cisplatin-induced oto- and nephrotoxicity in zebrafish and human cell line models.
Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey
Dominique Förster et al.
The retinotectal map in zebrafish exhibits location-specific, functional specializations to match prey object movement in the visual field during the hunting sequence.
Genetics and Genomics
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study
Chiara Fallerini et al.
In the context of susceptibility to severe COVID-19, the observations of a study provide the basis for a personalized interferon-based therapy in patients with rare TLR7 variants.
Physics of Living Systems
From local resynchronization to global pattern recovery in the zebrafish segmentation clock
Koichiro Uriu et al.
Theory explains how transport of gene expression vortices by cell advection may cause intermingled defective and normal segments along the body axis during resynchronization experiments in the zebrafish segmentation clock.
Mitochondrial fusion is required for spermatogonial differentiation and meiosis
Grigor Varuzhanyan et al.
Mitochondrial fusion enables a metabolic transition during spermatogenesis.
Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma
Connor Rogerson et al.
Genome-wide redistribution of KLF5 binding leads to activation of a cell cycle gene expression programme and proliferation control in oesophageal cancer.
Chromosomes and Gene Expression
Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation
Ava C Carter et al.
A long noncoding RNA uses viral mimicry to achieve developmental gene silencing across a chromosome.
Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in
Nathan Cermak et al.
Simultaneous quantification of each of the main motor programs in the roundworm
yields new insights into the neural mechanisms that coordinate animal behavior.
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