Kevin I Manage, Alicia K Rogers ... Carolyn Marie Phillips
SIMR-1 acts downstream of the piRNA pathway to promote siRNA amplification by the Mutator complex and localizes to perinuclear foci distinct from Mutator foci, P granules and Z granules.
Lisa Baumgartner, Dominik Handler ... Julius Brennecke
Kipferl, a ZAD zinc finger protein from Drosophila, determines the chromatin binding specificity of the heterochromatin protein variant Rhino, defining piRNA clusters and preventing Rhino sequestration by selfish Satellite repeats.
Jonathan M Stokes, Joseph H Davis ... Eric D Brown
The anticonvulsant drug lamotrigine inhibits bacterial ribosome biogenesis and reveals an unexplored role for initiation factor 2 (IF2) in ribosome assembly.
Uri Seroussi, Andrew Lugowski ... Julie M Claycomb
Systematically studying the expression, small RNA-binding partners, and loss-of-function phenotypes of all 19 Argonautes uncovers how small RNA regulatory pathways function and interact in Caenorhabditis elegans, a long-standing model for small RNA biology and RNAi.
Piotr Karaś, Klaudia Kochanowicz ... Krzysztof Liberek
Phylogenetic and biochemical analysis reveals crucial role of two substitutions in the α–crystallin domain for development of new functionality of IbpA chaperone after the loss of paralogous IbpB in Erwiniaceae.
Linker histone H1 and cytosine DNA methylation in contexts other than CG explain patterns of 24 nucleotide small RNA biogenesis in Arabidopsis thaliana.
Nathan R Johnson, Luis F Larrondo ... Elena A Vidal
A critical assessment of published microRNA/microRNA-like provides clues on features and conservation of these hairpin RNAs in fungi in addition to a centralized loci annotation resource for the community.
Jeroen Overman, Frank Fontaine ... Mathias Francois
A novel molecular strategy to block transcription factor activity using small molecule interference of multiple protein-protein interactions is reported.
The olfactory learning of Caenorhabditis elegans shows that the exonuclease and helicase domains of human Werner syndrome protein (WRN) coordinately regulate the biogenesis of small interfering RNAs to promote neuronal plasticity.
The LINC complex has a core 6:6 structure in which KASH-binding induces head-to-head interactions between SUN trimers, suggesting force transduction between cytoskeletal and nuclear components through branched LINC complex networks.
