5,877 results found
    1. Neuroscience

    Sucrose intensity coding and decision-making in rat gustatory cortices

    Esmeralda Fonseca et al.
    The neural representation of perceived sucrose intensity was contained in the firing rate and spike-timing of a 'small' population of neurons distributed across the Insula and Orbitofrontal taste cortices.
    1. Epidemiology and Global Health

    Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor

    Hui Liu et al.
    Smoking, measured by both initiation and intensity, are significantly associated with an elevated expression level of ACE2 in multiple human tissues/organs, subsequently increasing the susceptibility and severity of COVID-19.
    1. Cell Biology
    2. Developmental Biology

    First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass

    Guangliang Wang et al.
    A novel high-throughput, whole organism chemical screening platform was used to identify existing drugs that increase pancreatic beta-cell mass in zebrafish, implicating unique roles for the NF-κB and serotonergic signaling pathways in regulating pancreatic biology.
    1. Cell Biology

    The Nesprin-1/-2 ortholog ANC-1 regulates organelle positioning in C. elegans independently from its KASH or actin-binding domains

    Hongyan Hao et al.
    The giant KASH protein ANC-1 maintains the integrity of the cytoplasm to anchor nuclei, ER, and other organelles within the cell.
    1. Neuroscience

    Sources of widefield fluorescence from the brain

    Jack Waters
    Widefield fluorescence from the brain arises from greater depth and area than typically appreciated and is usually a weighted average across cortical columns and often more than one cortical area.
    1. Neuroscience

    Synchronized amplification of local information transmission by peripheral retinal input

    Pablo D Jadzinsky, Stephen A Baccus
    Peripheral retinal input transiently amplifies information transmission from ganglion cells, dynamically allocating the resources of neural activity to times of expected high information content.
    1. Physics of Living Systems
    2. Cell Biology

    Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation

    Robert J Huebner et al.
    Very local molecular patterns impart precise changes in the local mechanics of individual cell-cell junctions.
    1. Computational and Systems Biology
    2. Neuroscience

    From behavior to circuit modeling of light-seeking navigation in zebrafish larvae

    Sophia Karpenko et al.
    Light-seeking strategies in Zebrafish larvae are dissected using a virtual-reality assay, and these data are used to establish minimal stochastic and neural-circuits models that quantitatively capture this behavior.
    1. Developmental Biology
    2. Plant Biology

    Temporal integration of auxin information for the regulation of patterning

    Carlos S Galvan-Ampudia et al.
    Rhythmic centrifugal waves of auxin traveling through the tissue provides high definition positional information to cells that is not only spatial but also temporal.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Global morphogenetic flow is accurately predicted by the spatial distribution of myosin motors

    Sebastian J Streichan et al.
    Epithelial tissue remodeling during Drosophila embryonic development is quantitatively described by a simple law relating myosin activity and cell flow.

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