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    1. Cancer Biology
    2. Neuroscience

    Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer

    Jeffrey Barr, Austin Walz ... Paola D Vermeer
    Nerve tracing and behavioral studies in tumor-bearing mice together with transcriptional and functional analysis reveal cancer-induced central and peripheral neuronal alterations that influence behavior.
    1. Medicine

    Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans

    Yifan Xiang, Vineeta Tanwar ... Pankaj Kapahi
    Not revised
    Reviewed Preprint v1
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    • Solid
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma

    Nicole Laurencia Yuwono, Kristina Warton, Caroline Elizabeth Ford
    Circulating cell-free DNA studies should control for participants' physical activity to avoid its confounding effect on total cell-free DNA level.
    1. Neuroscience

    The effects of psychosocial stress on dopaminergic function and the acute stress response

    Michael AP Bloomfield, Robert A McCutcheon ... Oliver Howes
    Imaging and laboratory-induced psychosocial stress showed that exposure to psychosocial adversity was associated with dampened striatal dopaminergic function alongside blunted physiological yet potentiated subjective responses to acute stress.
    1. Immunology and Inflammation
    2. Medicine

    Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice

    Alex Moshensky, Cameron S Brand ... Laura E Crotty Alexander
    Chronic, daily inhalation of e-cigarette aerosols alters the inflammatory state of multiple organ systems, including the brain, heart, lung and colon.
    1. Neuroscience

    Associability-modulated loss learning is increased in posttraumatic stress disorder

    Vanessa M Brown, Lusha Zhu ... Pearl H Chiu
    Veterans with PTSD show increased attention to a history of unexpected outcomes during loss learning, both as measured by computational model-derived behavioral parameters and in increased neural signaling in amygdala and insula.
    1. Computational and Systems Biology

    Systematic integration of biomedical knowledge prioritizes drugs for repurposing

    Daniel Scott Himmelstein, Antoine Lizee ... Sergio E Baranzini
    Project Rephetio combines data integration and systematic analysis to enable drug repurposing predictions on an unprecedented scale.
    1. Neuroscience

    Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology

    Xiling Bian, Jiemin Zhu ... Yi Rao
    While neurotransmitters were discovered decades ago, evidence suggests that more transmitters are to be discovered using the presented approaches.
    1. Epidemiology and Global Health

    Risk of psychiatric disorders among the surviving twins after a co-twin loss

    Huan Song, Henrik Larsson ... Unnur A Valdimarsdóttir
    A population-based analysis demonstrates that surviving twins who lose their co-twins by death are at considerably elevated risks of developing psychiatric disorders.