942 results found
    1. Physics of Living Systems

    Increasing evidence of mechanical force as a functional regulator in smooth muscle myosin light chain kinase

    Fabian Baumann et al.
    Atomic force microscopy based single-molecule force spectroscopy of smooth muscle myosin light chain kinase strongly indicates the existence of a mechanically triggerable activation pathway analogous to its well-established biochemical regulation pathway via calcium-loaded calmodulin.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart

    Amy Heidersbach et al.
    microRNA-1 plays an essential role in the development and functioning of the heart by ensuring that genes for striated, rather than smooth, muscle are expressed there.
    1. Neuroscience

    Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

    Luis Alarcon-Martinez et al.
    Pericytes surrounding capillaries in the retina contain α-smooth muscle actin, demonstrating that pericytes have the necessary molecular machinery to change capillary diameter during neurovascular coupling.
    1. Chromosomes and Gene Expression

    Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers

    Erick E Nakagaki-Silva et al.
    By focusing on RNA-binding proteins whose genes have super enhancers in smooth muscle cells, the protein RBPMS was identified as an alternative splicing master regulator.
    1. Neuroscience
    2. Physics of Living Systems

    Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

    Simon Bulley et al.
    Arterial myocyte PKD2 channels are activated by vasoconstrictor stimuli, which increases blood pressure, are upregulated during hypertension and cell-specific knockout in vivo reduces both physiological blood pressure and hypertension.
    1. Developmental Biology

    Pericytes are progenitors for coronary artery smooth muscle

    Katharina S Volz et al.
    Progenitor cells for the muscle layer around the coronary arteries have been identified revealing a key step in how the embryo forms these important blood vessels.
    1. Developmental Biology
    2. Evolutionary Biology

    The evolutionary origin of bilaterian smooth and striated myocytes

    Thibaut Brunet et al.
    Molecular profiling of annelid myocytes reveals that the last common protostome-deuterostome ancestor already possessed a dual musculature, with visceral smooth muscles ensuring digestion and somatic striated muscles ensuring locomotion.
    1. Developmental Biology

    A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree

    Marta Losa et al.
    The transcription factor GATA6 selects the embryonic vessels that will be reorganized into the major thoracic arteries by promoting local differentiation of vascular smooth muscle cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1)

    Joshua J Filter et al.
    Unfair competition, in which a phosphatase and a phosphoprotein inhibitor/substrate mutually sequester each other from competing substrates and enzymes, is a conserved mechanism for the control of PPP family phosphatases.

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